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Titolo:
Evaluation of the percutaneous intramyocardial injection for local myocardial treatment
Autore:
Rezaee, M; Yeung, AC; Altman, P; Lubbe, D; Takeshi, S; Schwartz, RS; Stertzer, S; Altman, JD;
Indirizzi:
Stanford Univ Hosp, Div Cardiovasc Med, Stanford, CA 94305 USA Stanford Univ Hosp Stanford CA USA 94305 vasc Med, Stanford, CA 94305 USA BioCardia Inc, S San Francisco, CA USA BioCardia Inc S San Francisco CA USA Cardia Inc, S San Francisco, CA USA Mayo Clin & Mayo Fdn, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Fdn, Rochester, MN 55905 USA
Titolo Testata:
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
fascicolo: 2, volume: 53, anno: 2001,
pagine: 271 - 276
SICI:
1522-1946(200106)53:2<271:EOTPII>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST-GROWTH-FACTOR; GENE-THERAPY; ANGIOGENESIS; INTRACORONARY; ISCHEMIA; TRIAL; VEGF;
Keywords:
catheter; angiogenesis; local delivery; growth factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Rezaee, M Stanford Med Ctr, Falk Cardiovasc Inst, 300 Pasteur Dr, Stanford, CA 94305USA Stanford Med Ctr 300 Pasteur Dr Stanford CA USA 94305 A 94305USA
Citazione:
M. Rezaee et al., "Evaluation of the percutaneous intramyocardial injection for local myocardial treatment", CATHET C IN, 53(2), 2001, pp. 271-276

Abstract

Therapeutic angiogenesis requires the induction of new blood vessel formation for the treatment of peripheral vascular and coronary artery disease, Efficacious application of this new therapy requires optimizing multiple factors, including the therapeutic agent, dosing, frequency of administration,and delivery modality. In this study, a helical needle drug infusion catheter was applied for optimal application of percutaneous intramyocardial delivery (PIMD). (125)Iodine-labeled albumin was injected by PIMD into the left ventricle myocardium in eight swine. After 1 hr, PIMD resulted in a high concentration of radiolabel at the treatment site; 16.4% +/- 2.1% of delivered and 81.4% +/- 2.6% of the total cardiac activity was concentrated at the site of delivery. The depth of needle penetration correlated with the myocardial retention of delivered protein. The myocardial retention of radiolabel in animals with shallow injections was 10.1% +/- 0.8%, compared to 18.9% +/- 3.3% retention after deep injections. The specific activity at the treatment site (radioactive counts per gram of tissue) was 115 +/- 36, 226 +/- 55, and 47 +/- 10 times higher compared to liver, lung, and kidney, respectively. Continuous coronary sinus and aortic blood sampling indicates thatwithin 15 min following intramyocardial injection, a significant amount ofnonretained protein is found within the coronary sinus, This study definessome of the parameters that can affect optimal application of PIMD and demonstrates that PIMD is a safe and efficient method for local drug delivery,(C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:40:53