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Titolo:
Minor myocardial injury after elective uncomplicated successful PTCA with or without stenting: Detection by cardiac troponins
Autore:
Saadeddin, SM; Habbab, MA; Sobki, SH; Ferns, GA;
Indirizzi:
Riyadh Armed Forces Hosp, Riyadh 11159, Saudi Arabia Riyadh Armed Forces Hosp Riyadh Saudi Arabia 11159 h 11159, Saudi Arabia Prince Sultan Cardiac Ctr, Riyadh, Saudi Arabia Prince Sultan Cardiac CtrRiyadh Saudi Arabia Ctr, Riyadh, Saudi Arabia
Titolo Testata:
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
fascicolo: 2, volume: 53, anno: 2001,
pagine: 188 - 192
SICI:
1522-1946(200106)53:2<188:MMIAEU>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSLUMINAL CORONARY ANGIOPLASTY; CREATINE KINASE-MB; STABLE ANGINA-PECTORIS; PROGNOSTIC VALUE; UNSTABLE ANGINA; MUSCLE-CONTRACTION; RELEASE; INFARCTION; RISK; EVENTS;
Keywords:
myocardial injury; cardiac troponins; coronary angioplasty; coronary stenting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Saadeddin, SM Riyadh Armed Forces Hosp, POB 7897-R715, Riyadh 11159, SaudiArabia Riyadh Armed Forces Hosp POB 7897-R715 Riyadh Saudi Arabia 11159
Citazione:
S.M. Saadeddin et al., "Minor myocardial injury after elective uncomplicated successful PTCA with or without stenting: Detection by cardiac troponins", CATHET C IN, 53(2), 2001, pp. 188-192

Abstract

Cardiac troponins are sensitive and specific markers for the detection of minor myocardial injury. However, they have been rarely used to monitor myocardial injury after coronary stenting. The purpose of the study was to measure cardiac troponin I (cTnI) and cardiac troponin T (cTnT levels after elective uncomplicated successful percutaneous transluminal coronary angioplasty (PTCA) with or without coronary stenting and to compare their results with serum creatinine kinase MB isoenzyme (CKMB). CTnI and cTnT levels were compared with those of CK or CKMB in 98 consecutive patients with stable angina undergoing elective uncomplicated successful PTCA with stenting (n = 71) or without stenting (n = 27). Markers were measured before and 6, 12, 24, and 48 hr after the procedure. Peak postprocedural levels for each markerwere compared and related to angiographic and procedural characteristics as well as to the occurrence of sidebranch occlusion. None of the patients had abnormal markers before the procedure. Abnormal postprocedural values ofone or more markers were observed in 28 patients (29%), 23 after stenting and 5 after PTCA alone. The frequencies of abnormal cTnI and cTnT levels were significantly higher than that of CKMB after coronary intervention (26% and 18% vs. 7%; P = 0.00016 and 0.015, respectively), with cTnI being the most significant. When compared with troponin-negative patients, abnormal cardiac troponin values were significantly related to total time of inflation(223 +/- 128 vs. 170 +/- 105 sec; P = 0.008) and inflation maximal pressure (12.9 +/- 2.3 vs. 12.0 +/- 2.7 atm; P = 0.04). Small side-branch occlusion was noticed in 36% of the troponin-positive patients and in 6% of the troponin-negative group (P = 0.00047). In conclusion, minor myocardial injury is not uncommon after elective uncomplicated successful PTCA with or without stenting. Cardiac troponins, especially cTnI, are more sensitive than CKMB for the detection of this minor myocardial injury. Total time of inflation and inflation maximal pressure are predictors of postprocedural elevationof cardiac troponins. Side-branch occlusion may account for some, but not all, periprocedural minor myocardial injury. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 04:34:14