Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Transmural repolarisation in the left ventricle in humans during normoxia and ischaemia
Autore:
Taggart, P; Sutton, PMI; Opthof, T; Coronel, R; Trimlett, R; Pugsley, W; Kallis, P;
Indirizzi:
Middlesex Hosp, Dept Cardiol, London, England Middlesex Hosp London England lesex Hosp, Dept Cardiol, London, England Middlesex Hosp, Dept Cardiothorac Surg, London, England Middlesex Hosp London England , Dept Cardiothorac Surg, London, England Univ Coll London Hosp, Hatter Inst Cardiovasc Studies, London WC1E 6DB, England Univ Coll London Hosp London England WC1E 6DB , London WC1E 6DB, England Univ Med Ctr, Dept Med Physiol, Utrecht, Netherlands Univ Med Ctr Utrecht Netherlands Dept Med Physiol, Utrecht, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Expt & Mol Cardiol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands
Titolo Testata:
CARDIOVASCULAR RESEARCH
fascicolo: 3, volume: 50, anno: 2001,
pagine: 454 - 462
SICI:
0008-6363(200106)50:3<454:TRITLV>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATION-RECOVERY INTERVALS; ACTION-POTENTIAL DURATION; TRANSIENT OUTWARD CURRENT; GUINEA-PIG VENTRICLE; M-CELL; I-KS; ELECTROPHYSIOLOGICAL PROPERTIES; ENDOCARDIAL MYOCYTES; CANINE VENTRICLE; PORCINE HEART;
Keywords:
ischaemia; repolarisation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Taggart, P Middlesex Hosp, Dept Cardiol, London, England Middlesex Hosp London England Dept Cardiol, London, England
Citazione:
P. Taggart et al., "Transmural repolarisation in the left ventricle in humans during normoxia and ischaemia", CARDIO RES, 50(3), 2001, pp. 454-462

Abstract

Background: Studies in isolated tissues and myocytes show different repolarisation properties in subepicardium, midmyocardium and subendocardium. Whether these differences are present in vivo and are relevant to humans has been the subject of controversy, Our objectives were (1) to ascertain whether transmural repolarisation gradients are present in humans, (2) to determine whether the greater sensitivity of subepicardial cells to ischaemia in vitro is manifest during early ischaemia in humans in vivo, Methods and results: We studied 21 patients during routine coronary artery surgery. Unipolar activation recovery intervals (ARI) were recorded from five transmural locations between subepicardium and subendocardium in the left ventricular wall. A pacing protocol spanned a range of cycle lengths from a cycle length of 300 ms to the maximum permitted by the intrinsic atrial activity. Following the onset of cardiopulmonary bypass recordings were obtained before (control) and during a 3-min period of global ischaemia. During control transmural ARIs were homogeneous between 300 and 1500 ms (ventricular pacing) and750 and 1500 ms (atrial spontaneous brats), During ischaemia, ARIs shortened similarly at all transmural electrode sites and transmural homogeneity was maintained, Conclusions: Transmural repolarisation differences within the ventricular wall of the human heart were absent at cycle lengths within the physiological range but also during prolonged cycles. During early (global) ischaemia repolarisation changed equally in subepicardial and subendocardial regions and transmural homogeneity of repolarisation was preserved. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 08:04:41