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Titolo:
Overexpression of the retinoic acid-responsive gene Stra6 in human cancersand its synergistic induction by Wnt-1 and retinoic acid
Autore:
Szeto, W; Jiang, W; Tice, DA; Rubinfeld, B; Hollingshead, PG; Fong, SE; Dugger, DL; Pham, T; Yansura, DG; Wong, TA; Grimaldi, JC; Corpuz, RT; Singh, JS; Frantz, GD; Devaux, B; Crowley, CW; Schwall, RH; Eberhard, DA; Rastelli, L; Polakis, P; Pennica, D;
Indirizzi:
Genentech Inc, Dept Med Oncol, S San Francisco, CA 94080 USA Genentech Inc S San Francisco CA USA 94080 S San Francisco, CA 94080 USA Genentech Inc, Dept Prot Chem, S San Francisco, CA 94080 USA Genentech Inc S San Francisco CA USA 94080 S San Francisco, CA 94080 USA Genentech Inc, Dept Antibody Technol, S San Francisco, CA 94080 USA Genentech Inc S San Francisco CA USA 94080 S San Francisco, CA 94080 USA Genentech Inc, Dept Mol Biol, S San Francisco, CA 94080 USA Genentech IncS San Francisco CA USA 94080 S San Francisco, CA 94080 USA Genentech Inc, Dept Pathol, S San Francisco, CA 94080 USA Genentech Inc SSan Francisco CA USA 94080 S San Francisco, CA 94080 USA Genentech Inc, Dept Med Oncol, S San Francisco, CA 94080 USA Genentech Inc S San Francisco CA USA 94080 S San Francisco, CA 94080 USA CuraGen Corp, Dept Gene Discovery, New Haven, CT 06511 USA CuraGen Corp New Haven CT USA 06511 ne Discovery, New Haven, CT 06511 USA
Titolo Testata:
CANCER RESEARCH
fascicolo: 10, volume: 61, anno: 2001,
pagine: 4197 - 4205
SICI:
0008-5472(20010515)61:10<4197:OOTRAG>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CATENIN GENE; MAMMARY EPITHELIAL-CELLS; EXON 3 MUTATIONS; F-BOX PROTEIN; ESCHERICHIA-COLI; HEPATOCELLULAR CARCINOMAS; COLORECTAL-CANCER; NUCLEOTIDE-SEQUENCE; EXPRESSION ANALYSIS; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Pennica, D Genentech Inc, Dept Med Oncol, 1 DNA Way,MS 40, S San Francisco, CA 94080 USA Genentech Inc 1 DNA Way,MS 40 S San Francisco CA USA 94080 USA
Citazione:
W. Szeto et al., "Overexpression of the retinoic acid-responsive gene Stra6 in human cancersand its synergistic induction by Wnt-1 and retinoic acid", CANCER RES, 61(10), 2001, pp. 4197-4205

Abstract

Genetic defects in the Wnt-1 signaling pathway contribute to human tumor progression and are especially prevalent in colorectal cancer. We screened mouse C57MG cells to isolate mRNAs induced by Wnt-1 and identified Stra6, anmRNA known to be up-regulated by retinoic acid. Up-regulation of Stra6 mRNA was also observed in hyperplastic mammary tissue and mammary gland tumorsfrom transgenic mice expressing Wnt-1 and in human tumors that frequently harbor defects in Wnt-1 signaling. Stimulation of C57MG cells with retinoicacid plus Wnt-1 resulted in expression of Stra6 transcript to levels greatly exceeding that observed with either stimulus alone. This synergy could be explained in part by the up-regulation of retinoic acid receptor-gamma that was observed in response to Wnt-1 signaling. Accordingly, treatment of human colorectal cancer cell lines with retinoic acid resulted in the up-regulation of Stra6 mRNA and accumulation of Stra6 protein at the cell membrane. The data support a model in which Wnt1 signaling synergizes with retinoids to activate retinoic acid receptor-gamma -responsive genes in human cancers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:49:37