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Titolo:
Expression of p53 protein related to smoking and alcoholic beverage drinking habits in patients with esophageal cancers
Autore:
Kato, H; Yoshikawa, M; Miyazaki, T; Nakajima, M; Fukai, Y; Tajima, K; Masuda, N; Tsukada, K; Fukuda, T; Nakajima, T; Kuwano, H;
Indirizzi:
Gunma Univ, Fac Med, Dept Surg 1, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 1, Maebashi, Gumma 3718511, Japan Gunma Canc Ctr, Dept Surg, Ohta 3730828, Japan Gunma Canc Ctr Ohta Japan3730828 nc Ctr, Dept Surg, Ohta 3730828, Japan Gunma Univ, Fac Med, Dept Pathol 2, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 2, Maebashi, Gumma 3718511, Japan
Titolo Testata:
CANCER LETTERS
fascicolo: 1, volume: 167, anno: 2001,
pagine: 65 - 72
SICI:
0304-3835(20010610)167:1<65:EOPPRT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; PROGNOSTIC-SIGNIFICANCE; GENETIC ALTERATIONS; LUNG-CANCER; MUTATIONS; OVEREXPRESSION; FREQUENT; TUMORS;
Keywords:
esophageal cancer; p53; tobacco smoking; alcohol consumption;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Kato, H Gunma Univ, Fac Med, Dept Surg 1, 3-39-22 Showa Machi, Maebashi, Gumma 3718511, Japan Gunma Univ 3-39-22 Showa Machi Maebashi Gumma Japan 3718511 Japan
Citazione:
H. Kato et al., "Expression of p53 protein related to smoking and alcoholic beverage drinking habits in patients with esophageal cancers", CANCER LETT, 167(1), 2001, pp. 65-72

Abstract

In esophageal squamous cell carcinoma (SCC), we used immunohistochemical analysis to further elucidate the correlation of p53 protein expression withclinicopathological factors, as well as with risk factors, such as tobaccosmoking, alcohol consumption and a family history of cancer, using odds ratios (ORs). The expression of p53 protein was demonstrated in 55.1% of 89 esophageal SCC cases examined by immunohistochemistry. The expression of p53protein did not correlate with gender, age, histological grading, lymph node metastasis, or TNM stage. The prevalence of p53 expression was significantly higher in patients with multiple primary esophageal cancers (P < 0.05). p53 expression did not correlate with prognosis in univariate survival analysis. The esophageal SCC in either smokers or alcohol users was 4.67-5.83times more likely to express p53 protein, while the likelihood of p53 expression in patients who use both tobacco and alcohol was more than 14.0 times. However, a significant association was not found between p53 expression and a family history of cancer, this having an OR as low as 1.85. The expression of p53 protein did not correlate with clinicopathological factors andprognosis in univariate and multivariate survival analyses. In contrast, tobacco smoking and alcohol consumption were shown to be strongly associatedwith p53 mutations in esophageal carcinogenesis. (C) 2001 Elsevier ScienceIreland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/18 alle ore 08:24:39