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Titolo:
Cerebrospinal fluid gastrin releasing peptide in the diagnosis of leptomeningeal metastases from small cell carcinoma
Autore:
Castro, MP; McDonald, TJ; Qualman, SJ; Odorisio, TM;
Indirizzi:
Glens Falls Canc Ctr, Glens Falls, NY 12801 USA Glens Falls Canc Ctr Glens Falls NY USA 12801 , Glens Falls, NY 12801 USA Univ Western Ontario, Univ Hosp, Endocrinol & Metab Serv, London, ON N6A 5A5, Canada Univ Western Ontario London ON Canada N6A 5A5 London, ON N6A 5A5, Canada Childrens Hosp, Dept Pathol, Columbus, OH 43205 USA Childrens Hosp Columbus OH USA 43205 Dept Pathol, Columbus, OH 43205 USA Univ Iowa, Dept Med, Vet Adm Med Ctr, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 Vet Adm Med Ctr, Iowa City, IA 52242 USA
Titolo Testata:
CANCER
fascicolo: 11, volume: 91, anno: 2001,
pagine: 2122 - 2126
SICI:
0008-543X(20010601)91:11<2122:CFGRPI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM METASTASES; AUTOCRINE GROWTH-FACTORS; LUNG-CANCER; TUMOR-MARKER; BIOPSY;
Keywords:
small cell carcinoma; leptomeningeal metastases; malignant meningitis; cerebrospinal fluid (CSF) tumor markers; gastrin releasing peptide (GRP); bombesin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Castro, MP Glens Falls Canc Ctr, 102 Pk St, Glens Falls, NY 12801 USA Glens Falls Canc Ctr 102 Pk St Glens Falls NY USA 12801 801 USA
Citazione:
M.P. Castro et al., "Cerebrospinal fluid gastrin releasing peptide in the diagnosis of leptomeningeal metastases from small cell carcinoma", CANCER, 91(11), 2001, pp. 2122-2126

Abstract

BACKGROUND, The clinical diagnosis of leptomeningeal metastases is often difficult to substantiate. Patients with an underlying malignancy typically present with neurologic symptoms referable to multiple levels of the neuraxis. Although most patients have an abnormal cerebrospinal fluid (CSF), lessthan 60% have evidence of malignant cells on cytologic examination from a single lumbar puncture, and the disease is usually advanced in patients with positive results. An elevated serum level of gastrin releasing peptide (GRP) in patients with small cell carcinoma has emerged as one of the most useful markers for disease activity. METHODS. A patient with small cell carcinoma presented with signs of meningitis and an abnormal CSF. However, the CSF gave repeatedly negative cytologic results. Hence, serum and CSF were analyzed for GRP. RESULTS. The CSF GRP level was elevated by more than six orders of magnitude above the serum level. An autopsy demonstrated extensive meningeal and parenchymal brain involvement by small cell carcinoma. CONCLUSIONS. The diagnosis of leptomeningeal metatases in patients with small cell carcinoma can be established by CSF GRP testing, even when cytologic examination is negative. Cancer 2001;91:2122-6. (C) 2001 American CancerSociety.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:54:31