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Titolo:
Prospective assessment of voiding and sexual function after traetment for localized prostate carcinoma - Comparison of radical prostatectomy to hormonobrachytherapy with and without external beam radiotherapy
Autore:
Fulmer, BR; Bissonette, EA; Petroni, GR; Theodorescu, D;
Indirizzi:
Univ Virginia, Hlth Sci Ctr, Dept Urol, Charlottesville, VA 22908 USA UnivVirginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Hlth Sci Ctr, Dept Hlth Evaluat Sci, Div Biostat & Epidemiol, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Hlth Sci Ctr, Dept Urol, Div Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA
Titolo Testata:
CANCER
fascicolo: 11, volume: 91, anno: 2001,
pagine: 2046 - 2055
SICI:
0008-543X(20010601)91:11<2046:PAOVAS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUALITY-OF-LIFE; SOURCE INTERSTITIAL BRACHYTHERAPY; RADIATION-THERAPY; DEFINITIVE RADIOTHERAPY; CANCER CONTROL; MEN; POTENCY; PRESERVATION; SYMPTOMS;
Keywords:
prostate neoplasms; urinary function; sexual function; brachytherapy; radical prostatectomy; external beam radiotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Theodorescu, D Univ Virginia, Hlth Sci Ctr, Dept Urol, Box 422, Charlottesville, VA 22908USA Univ Virginia Box 422 Charlottesville VA USA 22908 22908USA
Citazione:
B.R. Fulmer et al., "Prospective assessment of voiding and sexual function after traetment for localized prostate carcinoma - Comparison of radical prostatectomy to hormonobrachytherapy with and without external beam radiotherapy", CANCER, 91(11), 2001, pp. 2046-2055

Abstract

BACKGROUND. Voiding and sexual function after treatment are major determinants of quality of life in prostate carcinoma patients. Erectile dysfunction, incontinence, and urinary symptoms, both obstructive and irritative, have a significant negative impact on patient quality of life. This prospective study was undertaken to evaluate voiding, sexual function, and their impact on patients with localized prostate carcinoma who were treated with radical retropubic prostatectomy (RP) and to compare these patients with patients who were undergoing hormonobrachytherapy with external bean radiotherapy(HBTC) and patients who were undergoing hormonobrachytherapy without external beam radiotherapy (HBT). METHODS. Patients treated for localized prostate carcinoma with either RP or interstitial palladium-103 (Pd-103) HBTC or HBT were prospectively administered a voiding and sexual function questionnaire before any treatment was initiated and at posttreatment visits. Questionnaire components included the American Urological Association Symptom Score (AUASS) and specific items that addressed urinary control and sexual function from the University ofCalifornia at Los Angeles Prostate Cancer Index. Questionnaire results were compiled, and differences among treatment groups were assessed over time. RESULTS. From January 1997 to November 1999, 127 consecutive patients weretreated with either unilateral or bilateral nerve-sparing RP (42 patients), HBTC (40 patients) or HBT (45 patients) by 2 surgeons proficient in all procedures. Using the overall score and the obstructive subscale (OAUA) of the AUASS, the RP group showed a posttreatment decrease in scores compared with both HBTC and HBT groups. OAUA scores of HBTC and HBT groups were significantly greater than scores in RP patients over the course of the study. HBTC patients had increased irritative symptoms initially when compared withRP patients, and, although not statistically significant, the magnitude ofthe difference persisted over the course of the study. Total AUASS and subscale scores for the RP group returned to near baseline levels within 12 months. The use of incontinence pads was a criterion for urinary incontinence, and the proportion of patients returning to baseline continence was lowerin RP patients over the course of the study. No notable differences in Voiding Bother (VE) scores were found. Initially RP patients experienced worseSexual Function (SF) scores; however, scores for RP patients changed over time and approached the levels seen in HBTC patients at 18 months. The Sexual Function Bother (SFB) scores also were higher initially in the RP group but then decreased to similar levels observed for HBTC patients by 18 months. None of the treatment groups returned to near baseline SF or SFB scores during the course of this study. CONCLUSIONS. Comparison of voiding Function indicated that HBTC and HBT patients initially have more obstructive voiding symptoms, whereas urinary incontinence is initially worse in RP patients. Initially RP patients demonstrated worse SF and SFB scores, but RP patients returned to HBTC levels within 18 months. Cancer 2001;91:2046-55, (C) 2001 American Cancer Society.

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Documento generato il 04/08/20 alle ore 11:38:30