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Titolo:
Clinical characterization of pulmonary large cell neuroendocrine carcinomaand large cell carcinoma with neuroendocrine morphology
Autore:
Iyoda, A; Hiroshima, K; Toyozaki, T; Haga, Y; Fujisawa, T; Ohwada, H;
Indirizzi:
Chiba Univ, Sch Med, Inst Pulm Canc Res, Div Pathol,Chuo Ku, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 Div Pathol,Chuo Ku, Chiba 2608670, Japan Chiba Univ, Sch Med, Inst Pulm Canc Res, Div Surg, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 Canc Res, Div Surg, Chiba 2608670, Japan
Titolo Testata:
CANCER
fascicolo: 11, volume: 91, anno: 2001,
pagine: 1992 - 2000
SICI:
0008-543X(20010601)91:11<1992:CCOPLC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURO-ENDOCRINE NEOPLASMS; LUNG-CANCER; TUMORS; DIFFERENTIATION; MARKERS; CLASSIFICATION; SPECTRUM; CRITERIA;
Keywords:
pulmonary; large cell neuroendocrine carcinoma; neuroendocrine morphology; neuroendocrine differentiation; neuroendocrine feature;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Iyoda, A Chiba Univ, Sch Med, Inst Pulm Canc Res, Div Pathol,Chuo Ku, 1-8-1 Inohana, Chiba 2608670, Japan Chiba Univ 1-8-1 Inohana Chiba Japan 2608670 hiba 2608670, Japan
Citazione:
A. Iyoda et al., "Clinical characterization of pulmonary large cell neuroendocrine carcinomaand large cell carcinoma with neuroendocrine morphology", CANCER, 91(11), 2001, pp. 1992-2000

Abstract

BACKGROUND. Large cell carcinoma has been classified as four potential types based on its neuroendocrine morphology and evidence of neuroendocrine differentiation discernible by immunohistochemistry or electron microscopy. However, the clinical relation among these four categories has not been clearly defined. In 1999, the World Health Organization (WHO) categorized largecell neuroendocrine carcinoma as a variant of large cell carcinoma. MATERIAL AND METHODS. The authors analyzed 119 cases of large cell carcinoma from a total of 2070 primary lung carcinoma cases resected surgically between 1969-1999. Using light microscopy, electron microscopy, and immunohistochemical staining, the authors reclassified these cases into large cell neuroendocrine carcinoma (LCNEC), large cell carcinoma with neuroendocrine differentiation (LCCND), large cell carcinoma with neuroendocrine morphology(LCCNM), and classic large cell carcinoma (CLCC). RESULTS. In multivariate analyses, the authors found that large cell carcinoma with neuroendocrine features, which combined LCNEC, LCCND, and LCCNM, impacted both the overall survival and disease-free survival of patients. The clinical behavior of LCCNM was similar to that of LCNEC. CONCLUSIONS. Large cell carcinomas with neuroendocrine features appear to be more clinically aggressive than CLCCs. The authors' findings suggest that the histologic identification of neuroendocrine features in tumor tissue from patients diagnosed with large cell carcinoma of the lung may have clinical relevance. Cancer 2001;91:1992-2000. (C) 2001 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 10:48:27