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Titolo:
Combined phosphodiesterase inhibition and beta-blockade in the GI104313, decreases ischemia-induced arrhythmias in the rat
Autore:
Carceles, MD; Aleixandre, F; Fuente, T; Lopez-Vidal, J; Laorden, ML;
Indirizzi:
Univ Murcia, Sch Med, Dept Physiol & Pharmacol, E-30100 Murcia, Spain UnivMurcia Murcia Spain E-30100 siol & Pharmacol, E-30100 Murcia, Spain Univ Murcia, Sch Med, Pharmacol Unit, E-30100 Murcia, Spain Univ Murcia Murcia Spain E-30100 , Pharmacol Unit, E-30100 Murcia, Spain CSV Arrixaca Hosp, Dept Anaesthesiol, Murcia, Spain CSV Arrixaca Hosp Murcia Spain a Hosp, Dept Anaesthesiol, Murcia, Spain CSV Arrixaca Hosp, Dept Nucl Med, Murcia, Spain CSV Arrixaca Hosp MurciaSpain ixaca Hosp, Dept Nucl Med, Murcia, Spain
Titolo Testata:
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
fascicolo: 5, volume: 48, anno: 2001,
pagine: 486 - 492
SICI:
0832-610X(200105)48:5<486:CPIABI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE HEART-FAILURE; CORONARY-ARTERY LIGATION; ANESTHETIZED RAT; CYCLIC-AMP; VENTRICULAR-FIBRILLATION; MYOCARDIAL-INFARCTION; DYSRHYTHMIAS; MODEL; CARDIOMYOPATHY; VULNERABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Laorden, ML Univ Murcia, Fac Med, Dept Farmacol, E-30100 Murcia, Spain Univ Murcia Murcia Spain E-30100 acol, E-30100 Murcia, Spain
Citazione:
M.D. Carceles et al., "Combined phosphodiesterase inhibition and beta-blockade in the GI104313, decreases ischemia-induced arrhythmias in the rat", CAN J ANAES, 48(5), 2001, pp. 486-492

Abstract

Purpose: The purpose of the present study was to evaluate the effects of G11043 13, a chimeric molecule containing a phosphodiesterase inhibiting pyradazinone and a blocking phenox-propanolamine, on ischemia-induced arrhythmias in anesthetized rats. Method: The coronary artery was occluded 15 min after commencing drug administration and myocardial ischemia was maintained for 30 min during which the heart rate and mean blood pressure were recorded. Cyclic AMP and GMP were determined by radio-immunoassay. Results: G11043 13 (0.1 mu mol(.)kg(-1) plus 0.01 mu mol(.)kg(-1.)min(-1) or 1 mu mol(.)kg(-1) plus 0.1 mu mol(.)kg(-1.)min(-1)) decreased the incidence of Ventricular tachycardia (86% and 75%), ventricular fibrillation (28%, P <0.01 and 12%, P <0.001) and premature ventricular beats (164 +/- 27.0 and 114 +/- 28.5, P <0.05) following coronary artery ligation, resulting ina decrease in mortality (29% and 12%, P <0.05), Changes in cyclic nucleotide concentrations have been implicated in the genesis of ischemia-induced arrhythmias. However. in the pre sent study G11043 13 did not change the concentrations of adenosine 3 ': 5 ' -cyclic monophosphate (cyclic AMP) (1.0 +/- 0.07 pmol(.)mg(-1), 1.0 +/- 0.05 pmol(.)mg(-1)) or guanosine 3 ' : 5 ' -cyclic monophosphate (cyclic GMP) (0.025 +/- 0.008 pmol(.)mg(-1) protein. 0.017 +/- 0.004 pmol(.)mg(-1) protein) in the left ventricle during ischemia-induced arrhythmias in anesthetized rats compared to saline (0.9 +/- 0.1 pmol(.)mg(-1) and 0.013 +/- 0.002 pmol(.)mg(-1), respectively. Conclusion: Our results demonstrate that, in rats, G11043 13 induced a decrease in both incidence of arrhythmias and mortality which was not associated with changes in ventricular cyclic nucleotide content.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:51:17