Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Increased noradrenaline release from rat preoptic area during and after sevoflurane and isoflurane anesthesia
Autore:
Anzawa, N; Kushikata, T; Ohkawa, H; Yoshida, H; Kubota, T; Matsuki, A;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Anesthesiol, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan
Titolo Testata:
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
fascicolo: 5, volume: 48, anno: 2001,
pagine: 462 - 465
SICI:
0832-610X(200105)48:5<462:INRFRP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; INTRACRANIAL MICRODIALYSIS; SLEEP-WAKEFULNESS; HALOTHANE; BRAIN; NEURONS; INVOLVEMENT; INDUCTION; RESPONSES; LESION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Anzawa, N 5 Zaifucho, Hirosaki, Aomori 0368562, Japan 5 Zaifucho HirosakiAomori Japan 0368562 Aomori 0368562, Japan
Citazione:
N. Anzawa et al., "Increased noradrenaline release from rat preoptic area during and after sevoflurane and isoflurane anesthesia", CAN J ANAES, 48(5), 2001, pp. 462-465

Abstract

Purpose: To study the effects of sevoflurane and isoflurane on noradrenaline release from the rat preoptic area (POA). Method: Sixteen male Wistar rats were studied. A microdialysis probe with a 2 mm long semipermeable membrane was implanted in the POA. Dialysates were collected at intervals often minutes. After obtaining five control samples for 50 min. 30 min inhalation of 3% sevoflurane or 1.8% isoflurane was performed. After cessation of the inhalation, five more samples were obtainedfor 50 min as recovery phase. Noradrenaline (NA) concentration in the dialysates was measured by high pressure liquid chromatography with an electrochemical detector. Results: Both sevoflurane and isoflurane caused marked increases in NA release from the rat POA (sevoflurane 233% at 20 min. isoflurane 357% at ten minutes after the start of inhalation). The marked NA releases were also observed during the emergence from sevoflurane and isoflurane anesthesia (sevoflurane 269% at 20 min. isoflurane 368% at ten minutes in the recovery phase). Conclusion: This study suggests that enhanced release of NA in the POA during sevoflurane and isoflurane may explain the excitatory phase observed during the peri-anesthetic period with these agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:26:39