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Titolo:
Frequencies of thiopurine S-methyltransferase mutant alleles (TPMT*2, *3A,*3B and *3C) in 151 healthy Japanese subjects and the inheritance of TPMT*3C in the family of a propositus
Autore:
Kubota, T; Chiba, K;
Indirizzi:
Chiba Univ, Fac Pharmaceut Sci, Lab Biochem Pharmacol & Toxicol, Inage Ku,Chiba, Japan Chiba Univ Chiba Japan ochem Pharmacol & Toxicol, Inage Ku,Chiba, Japan SRL Inc, Res Testing Dept, Hachioji, Tokyo, Japan SRL Inc Hachioji Tokyo Japan c, Res Testing Dept, Hachioji, Tokyo, Japan
Titolo Testata:
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 5, volume: 51, anno: 2001,
pagine: 475 - 477
SICI:
0306-5251(200105)51:5<475:FOTSMA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC-POLYMORPHISM; AZATHIOPRINE; PHARMACOGENETICS; POPULATIONS; MECHANISMS; DEFICIENCY; TPMT;
Keywords:
genotype; Japanese; TPMT*3C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Chiba, K Chiba Univ, Fac Pharmaceut Sci, Lab Biochem Pharmacol & Toxicol, Inage Ku,1-33 Yayoi Cho, Chiba, Japan Chiba Univ 1-33 Yayoi Cho Chiba Japan 3 Yayoi Cho, Chiba, Japan
Citazione:
T. Kubota e K. Chiba, "Frequencies of thiopurine S-methyltransferase mutant alleles (TPMT*2, *3A,*3B and *3C) in 151 healthy Japanese subjects and the inheritance of TPMT*3C in the family of a propositus", BR J CL PH, 51(5), 2001, pp. 475-477

Abstract

Aims To determine the frequencies of four thiopurine S-methyltransferase (TPMT) mutant alleles, TPMT(star)2, (star)3A, (star)3B and (star)3C in a normal Japanese population. Methods Genotypes were determined in 151 Japanese subjects and in six family members of a propositus using polymerase chain reaction (PCR)-restriction fragment length polymorphism and allele-specific PCR assays. Results Only one TPMT(star)3C heterozygote was identified (gene frequency 0.3%). TPMT(star)2, (star)3A and (star)3B were not detected. In addition, TPMT(star)3C was found to have been inherited from the mother and passed on to the son of the propositus. Conclusions (TPMTC)-C-star3 appears to be most prevalent among the known mutant allele of TPMT in a Japanese population which may have some relevancefor the treatment of Japanese patients with thiopurine drugs.

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Documento generato il 01/04/20 alle ore 17:53:42