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Titolo:
The role of hormones, growth factors and their receptors in pituitary tumorigenesis
Autore:
Ezzat, S;
Indirizzi:
Univ Toronto, Dept Med, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 t Med, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp, Freeman Ctr Endocrine Oncol, Toronto, ON M5G 1X5, Canada MtSinai Hosp Toronto ON Canada M5G 1X5 ncol, Toronto, ON M5G 1X5, Canada
Titolo Testata:
BRAIN PATHOLOGY
fascicolo: 3, volume: 11, anno: 2001,
pagine: 356 - 370
SICI:
1015-6305(200107)11:3<356:TROHGF>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN-RELEASING-HORMONE; MESSENGER RIBONUCLEIC-ACIDS; DOPAMINE D2 RECEPTOR; VASOACTIVE INTESTINAL PEPTIDE; FOLLICLE-STIMULATING-HORMONE; PROLACTIN GENE-TRANSCRIPTION; ADENYLATE-CYCLASE ACTIVITY; TUMORS IN-VITRO; ANTERIOR-PITUITARY; GLUCOCORTICOID RECEPTOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
157
Recensione:
Indirizzi per estratti:
Indirizzo: Ezzat, S Univ Toronto, Dept Med, 600 Univ Ave,Rm 437, Toronto, ON M5G 1X5,Canada Univ Toronto 600 Univ Ave,Rm 437 Toronto ON Canada M5G 1X5 Canada
Citazione:
S. Ezzat, "The role of hormones, growth factors and their receptors in pituitary tumorigenesis", BRAIN PATH, 11(3), 2001, pp. 356-370

Abstract

Numerous factors have been shown to govern adenohypophysial cell proliferation, Human and animal models have documented that the hypothalamic trophichormone growth hormone-releasing hormone stimulates cell proliferation, and prolonged stimulation leads to tumor formation, Similarly, lack of dopaminergic inhibition of lactotrophs and lack of feedback suppression by adrenal, gonadal or thyroid hormones are implicated, perhaps through hypothalamicstimulatory mechanisms, in pituitary adenoma formation superimposed on hyperplasia, However, most pituitary tumors are not associated with underlyinghyperplasia, Overexpression of growth factors and their receptors, such asEGF, TGF alpha, EGF-R and VEGF has been identified in pituitary adenomas, and reduction of follistatin expression has been implicated in gonadotroph adenomas, Aberrant expression of members of the FGF family, an FGF antisense gene and FGF receptors have all been described in pituitary adenomas, Theclonal composition of pituitary adenomas attests to the molecular basis ofpituitary tumorigenesis, however, the evidence suggests that these varioushypophysiotropic hormones and growth factors likely play a role as promoters of tumor cell growth in genetically transformed cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:40:17