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Titolo:
Oncogene activation in pituitary tumors
Autore:
Yu, R; Melmed, S;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Cedars Sinai Res Inst, Los Angeles, CA 90048 USA Univ Calif Los Angeles Los Angeles CA USA 90048 Los Angeles, CA 90048 USA
Titolo Testata:
BRAIN PATHOLOGY
fascicolo: 3, volume: 11, anno: 2001,
pagine: 328 - 341
SICI:
1015-6305(200107)11:3<328:OAIPT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFORMING GENE PTTG; COMPARATIVE GENOMIC HYBRIDIZATION; SISTER-CHROMATID SEPARATION; HUMAN ENDOCRINE TUMORS; MYC-INDUCED APOPTOSIS; GS ALPHA-GENE; C-MYC; SUPPRESSOR GENE; CELL-CYCLE; P53-INDEPENDENT MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: Melmed, S Cedars Sinai Med Ctr, 2015,8700 Beverly Blvd, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr 2015,8700 Beverly Blvd Los Angeles CA USA 90048
Citazione:
R. Yu e S. Melmed, "Oncogene activation in pituitary tumors", BRAIN PATH, 11(3), 2001, pp. 328-341

Abstract

Pituitary tumors constitute 10% of intracranial neoplasms and are mostly benign, monoclonal adenomas derived from single mutant cells. Pituitary oncogenes have been intensively studied and three of them, gsp, ccnd1, and PTTGare abundant in significant numbers of cases. gsp is present in similar to40% of Caucasian patients with GH-secreting tumors and results from a mutated, constitutively active alpha subunit of Gs protein. Persistent activation of the CAMP-PKA-CREB pathway may lead to uncontrolled cell proliferationand GH secretion. ccnd1 is overexpressed cyclin Dl,and cyclin D1 gene is amplified in some pituitary tumors. PTTG is expressed in most pituitary tumors. PTTG is localized to both the nucleus and cytoplasm and interacts with several protein partners. At least three tumorigenesis mechanisms are proposed for human PTTG. 1) PTTG and FGF form a positive feedback loop and stimulate tumor vascularity. 2) PTTG transactivates c-myc or other pro-proliferation genes. 3) PTTG overexpression causes aneuploidy. PTTG expression activates p53 and causes p53-dependent and -independent apoptosis. Due to lack of functional human pituitary cell cultures and appropriate animal models for pituitary tumors, many of the results reviewed here are obtained from heterologous systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 13:21:31