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Titolo:
Expression of cell death-associated proteins in neuronal apoptosis associated with pontosubicular neuron necrosis
Autore:
Stadelmann, C; Mews, I; Srinivasan, A; Deckwerth, TL; Lassmann, H; Bruck, W;
Indirizzi:
Humboldt Univ, Charite, Dept Neuropathol, Berlin, Germany Humboldt Univ Berlin Germany Charite, Dept Neuropathol, Berlin, Germany Univ Gottingen, Dept Neuropathol, D-3400 Gottingen, Germany Univ Gottingen Gottingen Germany D-3400 athol, D-3400 Gottingen, Germany IDUN Pharmaceut, La Jolla, CA USA IDUN Pharmaceut La Jolla CA USAIDUN Pharmaceut, La Jolla, CA USA Univ Vienna, Dept Neuroimmunol, Inst Brain Res, A-1010 Vienna, Austria Univ Vienna Vienna Austria A-1010 Inst Brain Res, A-1010 Vienna, Austria
Titolo Testata:
BRAIN PATHOLOGY
fascicolo: 3, volume: 11, anno: 2001,
pagine: 273 - 281
SICI:
1015-6305(200107)11:3<273:EOCDPI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-ARTERY OCCLUSION; ISCHEMIC BRAIN INJURY; BCL-X; ALZHEIMERS-DISEASE; DNA FRAGMENTATION; NERVOUS-SYSTEM; RAT MODEL; DAMAGE; P53; BAX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Bruck, W Charite, Inst Neuropathol, Campus Virchow Klinikum,AugustenburgerPl 1, D-13353 Berlin, Germany Charite Campus Virchow Klinikum,Augustenburger Pl 1 Berlin Germany D-13353
Citazione:
C. Stadelmann et al., "Expression of cell death-associated proteins in neuronal apoptosis associated with pontosubicular neuron necrosis", BRAIN PATH, 11(3), 2001, pp. 273-281

Abstract

Expression of apoptosis-associated proteins p53, bcl-2, bax, and caspase-3/CPP32, activation of caspase-3, and modification of proteins via poly(ADP-ribosyl)ation was studied in pontosubicular neuron necrosis (PSN), a form of perinatal brain damage revealing the morphological hallmarks of neuronal apoptosis, Immunoreactivity for p53 was completely absent. The majority of cells stained with the bax and procaspase-3 antibodies did not show morphological signs of apoptosis, In contrast, an antibody against activated caspase-3 almost exclusively stained cells with apoptotic morphology, Poly(ADP-ribosyl)ated proteins were only rarely detected in cells with apoptotic morphology. The expression patterns of bax, procaspase-3, bcl-2, and p53 in PSNwere similar to that found in age-matched control brains, However, activated caspase-3 and poly-ADP-ribosylated proteins were exclusively found in apoptotic cells. These data indicate that detection of active caspase-3 is a reliable marker for apoptosis in formalin-fixed human tissue, and that neuronal apoptosis in pontosubicular neuron necrosis is accompanied by a pronounced activation of caspase-3.

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Documento generato il 04/04/20 alle ore 02:38:56