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Titolo:
Plasma levels of factor XIIa and factor VIIa are increased but not relatedin primary hyperlipidaemia
Autore:
Cardigan, RA; Crook, M; Mackie, IJ; Machin, SJ;
Indirizzi:
Univ Coll London, Sch Med, Dept Haematol, London W1N 8AA, England Univ Coll London London England W1N 8AA aematol, London W1N 8AA, England Guys Hosp, Dept Chem Pathol, London SE1 9RT, England Guys Hosp London England SE1 9RT pt Chem Pathol, London SE1 9RT, England
Titolo Testata:
BLOOD COAGULATION & FIBRINOLYSIS
fascicolo: 3, volume: 12, anno: 2001,
pagine: 187 - 192
SICI:
0957-5235(200104)12:3<187:PLOFXA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-HEART-DISEASE; ACTIVATED FACTOR-VII; TRIGLYCERIDE-RICH LIPOPROTEINS; COAGULATION-FACTOR-VII; MIDDLE-AGED MEN; RISK-FACTORS; MYOCARDIAL-INFARCTION; THROMBIN GENERATION; HEMOSTATIC FACTORS; TISSUE FACTOR;
Keywords:
coagulation; factor XIIa; factor VIIa; lipoprotein; triglyceride; cholesterol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Cardigan, RA Natl Blood Serv, Brentwood Ctr, Crescent Dr, Brentwood CM15 8DP, Essex, England Natl Blood Serv Crescent Dr Brentwood Essex England CM158DP
Citazione:
R.A. Cardigan et al., "Plasma levels of factor XIIa and factor VIIa are increased but not relatedin primary hyperlipidaemia", BL COAG FIB, 12(3), 2001, pp. 187-192

Abstract

The lipolysis of triglyceride-rich lipoproteins may provide a surface thatsupports the activation of factor XII (FXII) with subsequent activation offactor VII (FVII). Plasma levels of activated FVII (FVIIa) but not activated FXII (FXIIa) are increased in the post-prandial state when there is a transient increase in triglyceride levels. We compared plasma levels of FXIIaantigen in control subjects (n = 33) and in patients with chronically elevated lipids (primary hyperlipidaemia, n = 49), with FVIIa and markers of thrombin generation. Results are given as median (first and third quartiles). Plasma levels of FXIIa [2.34 (1.68-3.32) ng/ml versus 1.53 (0.93-1.86) ng/ml, P = 0.0002], FVIIa [3.02 (2.15-4.64) ng/ml versus 2.20 (1.66-2.56) ng/ml, P = 0.0004], thrombin-antithrombin complexes [3.08 (2.16-5.54) mug/l versus 2.13 (1.46-2.84) mug/l, P = 0.005] and prothrombin fragment 1 + 2 (Pro F1 + 2) [1.28 (1.08-1.50)nmol/l versus 0.92 (0.65-1.08)nmol/l, P=0.0001] were increased compared with controls irrespective of the type of hyperlipidaemia. In hyperlipdaemic subjects, levels of Pro F1+2 were correlated with FVIIa (r=0.56, P=0.0002) and FXIIa (r = 0.31, P = 0.03). These results suggest increased activation of both FVII and FXII in hyperlipidaemic subjects, which correlates with increased thrombin generation. Given the lack of correlation between levels of FXIIa and FVIIa, it remains to be established whether the increase in FXIIa is responsible for increased FVIIa activity in this subject group. Blood Coagul Fibrinolysis 12:187-192 (C) 2001 LippincottWilliams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 00:18:32