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Titolo:
Cytogenetic analysis and clinical significance in adult T-cell leukemia/lymphoma: a study of 50 cases from the human T-cell leukemia virus type-1 endemic area, Nagasaki
Autore:
Itoyama, A; Chaganti, RSK; Yamada, Y; Tsukasaki, K; Atogami, S; Nakamura, H; Tomonaga, M; Ohshima, K; Kikuchi, M; Sadamori, N;
Indirizzi:
Mem Sloan Kettering Canc Ctr, Canc Genet Lab, Cell Biol Program, New York,NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York,NY 10021 USA Nagasaki Univ, Sch Med, Dept Lab Med, Nagasaki, Japan Nagasaki Univ Nagasaki Japan iv, Sch Med, Dept Lab Med, Nagasaki, Japan Nagasaki Univ, Sch Med, Inst Atom Dis, Dept Hematol, Nagasaki, Japan Nagasaki Univ Nagasaki Japan st Atom Dis, Dept Hematol, Nagasaki, Japan Fukuoka Univ, Sch Med, Dept Pathol 1, Fukuoka, Japan Fukuoka Univ Fukuoka Japan Univ, Sch Med, Dept Pathol 1, Fukuoka, Japan Siebold Univ, Dept Nursing, Nagasaki, Japan Siebold Univ Nagasaki JapanSiebold Univ, Dept Nursing, Nagasaki, Japan
Titolo Testata:
BLOOD
fascicolo: 11, volume: 97, anno: 2001,
pagine: 3612 - 3620
SICI:
0006-4971(20010601)97:11<3612:CAACSI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMA; COMPARATIVE GENOMIC HYBRIDIZATION; TUMOR-SUPPRESSOR GENES; CHROMOSOME-ABNORMALITIES; BREAST CARCINOMAS; JAPANESE PATIENTS; ALLELIC LOSSES; ALPHA-CHAIN; BAND 14Q11; TCL1 LOCUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Itoyama, A Mem Sloan Kettering Canc Ctr, Canc Genet Lab, Cell Biol Program, 1275 YorkAve, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr 1275 York Ave New York NY USA 10021
Citazione:
A. Itoyama et al., "Cytogenetic analysis and clinical significance in adult T-cell leukemia/lymphoma: a study of 50 cases from the human T-cell leukemia virus type-1 endemic area, Nagasaki", BLOOD, 97(11), 2001, pp. 3612-3620

Abstract

Identification of cytogenetic abnormalities is an important clue for the elucidation of carcinogenesis. However, the cytogenetic and clinical significance of adult T-cell leukemia/lymphoma (ATLL) is still unclear To address this point, cytogenetic findings in 50 cases of ATLL were correlated with clinical characteristics. Karyotypes showed a high degree of diversity and complexity. Aneuploidy and multiple breaks (at least 6) were observed frequently in acute and lymphoma subtypes of ATLL. Breakpoints fended to cluster at specific chromosomal regions, although characteristic cytogenetic sub-groups of abnormalities were not found. Of these, aberrations of chromosomes 1p, 1q, 1q10-21, 10p, 10p13,12q,14q, and 14q32. correlated with one or moreof the following clinical features: hepatosplenomegaly, elevated lactate dehydrogenase, hypercalcemia, and unusual immunophenotype, all indicators ofclinical severity of ATLL. Multiple breaks (at least 6); abnormalities of chromosomes 1p, 1p22, 1q, 1q10-21, 2q, 3q, 3q10-12, 3q21,14q, 14q32, and 17q; and partial loss of chromosomes 2q, 9p, 14p, 14q, and 17q regions correlated with shorter survival. These cytogenetic findings are relevant in pre-dieting clinical outcome and provide useful information to identify chromosomal regions responsible for leukemogenesis. This study also indicates thatone model of an oncogenic mechanism, activation of a proto-oncogene by translocation of a T-cell-receptor gene, may not be applicable to the main pathway of development of ATLL and that a multistep process of leukemogenesis is required for the development of ATLL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:44:36