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Titolo:
Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells
Autore:
Hattori, K; Heissig, B; Tashiro, K; Honjo, T; Tateno, M; Shieh, JH; Hackett, NR; Quitoriano, MS; Crystal, RG; Rafii, S; Moore, MAS;
Indirizzi:
Sloan Kettering Inst Canc Res, James Ewing Lab Dev Hematopoiesis, New York, NY 10021 USA Sloan Kettering Inst Canc Res New York NY USA 10021 ew York, NY 10021 USA Cornell Univ, Weill Med Coll, Div Hematol Oncol, New York, NY USA Cornell Univ New York NY USA d Coll, Div Hematol Oncol, New York, NY USA New York Med Coll, Cornell Med Ctr, Div Pulm & Crit Care Med, New York, NYUSA New York Med Coll New York NY USA Pulm & Crit Care Med, New York, NYUSA Kyoto Univ, Ctr Mol Biol & Genet, Kyoto, Japan Kyoto Univ Kyoto JapanKyoto Univ, Ctr Mol Biol & Genet, Kyoto, Japan Kyoto Univ, Fac Med, Dept Med Chem, Kyoto, Japan Kyoto Univ Kyoto JapanKyoto Univ, Fac Med, Dept Med Chem, Kyoto, Japan Sapporo City Gen Hosp, Dept Pathol, Sapporo, Hokkaido, Japan Sapporo City Gen Hosp Sapporo Hokkaido Japan l, Sapporo, Hokkaido, Japan
Titolo Testata:
BLOOD
fascicolo: 11, volume: 97, anno: 2001,
pagine: 3354 - 3360
SICI:
0006-4971(20010601)97:11<3354:PEOSCF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEMOKINE RECEPTOR CXCR4; BONE-MARROW; TRANSENDOTHELIAL MIGRATION; ADHESION MOLECULE-1; FACTOR-I; ENDOTHELIAL SELECTINS; NOD/SCID MICE; EXPRESSION; SDF-1; LYMPHOPOIESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Moore, MAS Sloan Kettering Inst Canc Res, James Ewing Lab Dev Hematopoiesis, 1275 York Ave,Mailbox 101,Rm 717,RRL, New York, NY 10021 USA Sloan Kettering Inst Canc Res 1275 York Ave,Mailbox 101,Rm 717,RRL New York NY USA 10021
Citazione:
K. Hattori et al., "Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells", BLOOD, 97(11), 2001, pp. 3354-3360

Abstract

The chemokine, stromal cell-derived factor-1 (SDF1), is produced in the hone marrow and has been shown to modulate the homing of stem cells to this site by mediating chemokinesis and chemotaxis. Therefore, it was hypothesized that elevation of SDF1 level in the peripheral circulation would result in mobilization of primitive hematopoietic stem and progenitor cells. SDF1 plasma level was increased by intravenous injection of an adenoviral vector expressing SDF1 alpha (AdSDF1) into severe combined immunodeficient mice. This resulted in a 10-fold increase in leukocyte count, a 3-fold increase inplatelets, and mobilization of progenitors, including colony-forming units-granulocyte-macrophage to the peripheral circulation. In addition, AdSDF1 induced mobilization of cells with stem cell potential, including colony-forming units in spleen and long-term reconstituting cells. These data demonstrate that overexpression of SDF1 in the peripheral circulation results in the mobilization of hematopoietic cells with repopulating capacity, progenitor cells, and precursor cells, These studies lay the foundation for using SDF1 to induce mobilization of hematopoietic stem and progenitor cells in in vivo studies. (Blood. 2001;97:3354-3360) (C) 2001 by The American Societyof Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:04:52