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Titolo:
Preparation of nanoparticles composed with bioinspired 2-methacryloyloxyethyl phosphorylcholine polymer
Autore:
Konno, T; Kurita, K; Iwasaki, Y; Nakabayashi, N; Ishihara, K;
Indirizzi:
Univ Tokyo, Grad Sch Engn, Dept Mat Sci, Bunkyo Ku, Tokyo 1138656, Japan Univ Tokyo Tokyo Japan 1138656 Mat Sci, Bunkyo Ku, Tokyo 1138656, Japan Nihon Univ, Coll Sci & Technol, Dept Ind Chem, Chiyoda Ku, Tokyo 1018308, Japan Nihon Univ Tokyo Japan 1018308 nd Chem, Chiyoda Ku, Tokyo 1018308, Japan Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan Tokyo Med & Dent Univ Tokyo Japan 1010062 iyoda Ku, Tokyo 1010062, Japan
Titolo Testata:
BIOMATERIALS
fascicolo: 13, volume: 22, anno: 2001,
pagine: 1883 - 1889
SICI:
0142-9612(200107)22:13<1883:PONCWB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN ADSORPTION; PHOSPHOLIPID POLYMER; PLATELET-ADHESION; POLY(LACTIC ACID); DRUG-DELIVERY; SURFACES; METHACRYLATE); BLOOD; MOIETIES;
Keywords:
poly(L-lactic acid); phospholipid polymer; polymer nanoparticles; protein adsorption; drug carrier; diagnostic reagents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ishihara, K Univ Tokyo, Grad Sch Engn, Dept Mat Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1138656 kyo 1138656, Japan
Citazione:
T. Konno et al., "Preparation of nanoparticles composed with bioinspired 2-methacryloyloxyethyl phosphorylcholine polymer", BIOMATERIAL, 22(13), 2001, pp. 1883-1889

Abstract

The poly(L-lactic acid) nanoparticles immobilized with 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer, which has excellent blood compatibility, were prepared by a solvent evaporation technique using the water-solubleamphiphilic MPC polymer as an emulsifier and a surface modifier. The diameter and zeta -potential of the obtained nanoparticles strongly depended on the concentration of the MPC polymer. When the nanoparticles were prepared in 1.0 mg/ml of an MPC polymer aqueous solution, the diameter was 221 nm which was determined by atomic force microscopy and dynamic light scattering measurements. The X-ray photoelectron spectroscopic analysis indicated thatthe phosphorylcholine groups of the MPC unit were located at the surface of the nanoparticles, that is, the MPC polymer was immobilized on the PLA particles and the surface zeta -potential was -2.5 mV. Various hydrophobic fluorescence probes could permeate through the MPC polymer layer and adsorb on the PLA surface. The amount of bovine serum albumin adsorbed on the nanoparticles was significantly smaller compared with that on the conventional polystyrene nanoparticles. It is suggested that the nanoparticles immobilized with the MPC polymer have the potential for use as both a novel drug carrier and diagnostic reagent which can come in contact with blood components. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:27:17