Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Monozygotic twins incompletely concordant for narcolepsy
Autore:
Honda, M; Honda, Y; Uchida, S; Miyazaki, S; Tokunaga, K;
Indirizzi:
Tokyo Metropolitan Matsuzawa Hosp, Setagaya Ku, Tokyo 1560057, Japan TokyoMetropolitan Matsuzawa Hosp Tokyo Japan 1560057 kyo 1560057, Japan Seiwa Hosp, Neuropsychiat Res Inst, Tokyo, Japan Seiwa Hosp Tokyo JapanSeiwa Hosp, Neuropsychiat Res Inst, Tokyo, Japan Tokyo Inst Psychiat, Tokyo, Japan Tokyo Inst Psychiat Tokyo JapanTokyo Inst Psychiat, Tokyo, Japan Univ Tokyo, Fac Med, Dept Human Genet, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 d, Dept Human Genet, Tokyo 1130033, Japan
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 11, volume: 49, anno: 2001,
pagine: 943 - 947
SICI:
0006-3223(20010601)49:11<943:MTICFN>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUTATION;
Keywords:
narcolepsy; monozygotic twins; incomplete concordance; environmental factors; polysomnogram; HLA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Honda, M Tokyo Metropolitan Matsuzawa Hosp, Setagaya Ku, 2-1-1 Kamikitazawa, Tokyo 1560057, Japan Tokyo Metropolitan Matsuzawa Hosp 2-1-1 Kamikitazawa Tokyo Japan 1560057
Citazione:
M. Honda et al., "Monozygotic twins incompletely concordant for narcolepsy", BIOL PSYCHI, 49(11), 2001, pp. 943-947

Abstract

Background: Among 15 monozygotic twin pairs described in the literature, only four pairs were considered to be concordant There is no derailed reportof HLA-DRB1*1501/DQBI*0602 positive monozygotic twins concordant for narcolepsy, with marked difference in the age of onset. Methods: We compared a pair of female narcoleptic twins clinically. Results: Diagnosis of narcolepsy and monozygosity of the twins were confirmed. The second-born twin demonstrated a typical course of narcolepsy, whereas the first-born twin had a very late onset of recurrent daytime sleep episodes at age 45 and cataplexy at age 50 years, which was apparently triggered by chronic emotional stresses and sleep insufficiency. Conclusions: The atypical course of narcolepsy in the first-bent twin supports the multifactorial model for the development of narcolepsy. It was noted that cataplexy was preceded by sustained polyphasic sleep conditions. Our observation implies that the unaffected co-twins in discordant pairs could develop narcolepsy in stressful situations later in their lives. (C) 2001Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:32:40