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Titolo:
Double-blind naltrexone and placebo comparison study in the treatment of pathological gambling
Autore:
Kim, SW; Grant, JE; Adson, DE; Shin, YC;
Indirizzi:
Univ Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55454 USA Univ Minnesota Minneapolis MN USA 55454 ychiat, Minneapolis, MN 55454 USA Sung Kyun Kwan Univ, Kangbuk Samsung Hosp, Sch Med, Dept Psychiat, Seoul, South Korea Sung Kyun Kwan Univ Seoul South Korea Dept Psychiat, Seoul, South Korea
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 11, volume: 49, anno: 2001,
pagine: 914 - 921
SICI:
0006-3223(20010601)49:11<914:DNAPCS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMPULSE-CONTROL DISORDERS; FLUVOXAMINE; PREVALENCE; GAMBLERS; BEHAVIOR; ADDICTS; BULIMIA; TRIAL;
Keywords:
pathologic gambling; naltrexone; opioid antagonists; urges; impulse control;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, SW Univ Minnesota, Sch Med, Dept Psychiat, 2450 Riverside Ave,F256-2AW, Minneapolis, MN 55454 USA Univ Minnesota 2450 Riverside Ave,F256-2A W Minneapolis MN USA 55454
Citazione:
S.W. Kim et al., "Double-blind naltrexone and placebo comparison study in the treatment of pathological gambling", BIOL PSYCHI, 49(11), 2001, pp. 914-921

Abstract

Background: The authors' goal was to assess the efficacy and tolerability of naltrexone in the treatment of pathologic gambling disorder. Methods: Eighty-three subjects who met criteria for DSM-IV pathologic gambling disorder were enrolled in a I-week single-blind placebo lend-in followed by an 11-week double-blind naltrexone or placebo trial. Naltrexone was started at 25 mg/day and titrated upward until maximum symptom improvement or 250 mg/day was achieved Gambling symptom change was assessed with the patient-rated Clinical Global Impression (PG-CGI-PT), clinician-rated CGI (PG-CGI-MD), and the Gambling Symptom Rating Scale (G-SAS). Side effects were monitored weekly and liver function tests biweekly. Results: Data from 45 patients were analyzed Using random regression analysis, significant improvement was noted in all three gambling symptom measures: patient-rated Clinical Global Impression, p < .001; clinician-rated CGI, p < .001; Gambling Symptom Rating Scale, p < .019. At study end, 75% of subjects taking naltrexone were much or very much improved on both the PE-CEI PT and the PG-CGI-MD, compared with only 24% of those on placebo. Elevated liver enzymes occurred in four subjects who were taking analgesics concurrently. Nausea was common during the first week of treatment. Conclusions: Results suggest that naltrexone is effective in reducing the symptoms of pathologic gambling. Until further studies corroborate the present findings, our report should be interpreted cautiously. (C) 2001 Societyof Biological Psychiatry.

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Documento generato il 31/03/20 alle ore 10:03:09