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Titolo:
Peptide vaccines and peptide libraries
Autore:
Wiesmuller, KH; Fleckenstein, B; Jung, G;
Indirizzi:
EMC Microcollect GmbH, D-72070 Tubingen, Germany EMC Microcollect GmbH Tubingen Germany D-72070 D-72070 Tubingen, Germany Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 n Chem, D-72076 Tubingen, Germany
Titolo Testata:
BIOLOGICAL CHEMISTRY
fascicolo: 4, volume: 382, anno: 2001,
pagine: 571 - 579
SICI:
1431-6730(200104)382:4<571:PVAPL>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I MOLECULES; HISTOCOMPATIBILITY ANTIGEN; BORRELIA-BURGDORFERI; BINDING PEPTIDES; OUTER-MEMBRANE; HLA-DR; COMBINATORIAL LIBRARIES; VIRAL PEPTIDES; T-LYMPHOCYTES; MHC MOLECULES;
Keywords:
binding motif; lipopeptides; peptide libraries; synthetic vaccine;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Wiesmuller, KH EMC Microcollect GmbH, Sindelfinger Str 3, D-72070 Tubingen, Germany EMC Microcollect GmbH Sindelfinger Str 3 Tubingen Germany D-72070
Citazione:
K.H. Wiesmuller et al., "Peptide vaccines and peptide libraries", BIOL CHEM, 382(4), 2001, pp. 571-579

Abstract

Synthetic immunogens, containing built-in adjuvanticity, B cell, T helper cell and CTL epitopes or mimotopes, are ideal and invaluable tools to studythe immune response with respect to antigen processing and presentation. This serves as a basis for the development of complete and minimal vaccines which do not need large carrier proteins, further adjuvants, liposome formulations or other delivery systems. Combinatorial peptide libraries, either completely random or characterizedby one or several defined positions, are useful tools for the identification of the critical features of B cell epitopes and of MHC class I and classII binding natural and synthetic epitopes. The complete activity pattern of an O/X-n library with hundreds of peptide collections, each made up from billions of different peptides, represents the ranking of amino acid residues mediating contact to the target proteins of the immune system. Combinatorial libraries support the design of peptides applicable in vaccination against infectious agents as well as therapeutic tumour vaccines. Using the principle of lipopeptide vaccines, strong humoral and cellular immune responses could be elicited. The lipopeptide vaccines are heat-stable, non-toxic, fully biodegradable and can be prepared on the basis of minimized epitopes by modern methods of multiple peptide synthesis. The lipopeptides activate the antigen-presenting macrophages and B cells and have been recently shown to stimulate innate immunity by specific interaction with receptors of the Toll family.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 08:36:41