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Titolo:
Intracellular bacteria as targets and carriers for vaccination
Autore:
Mollenkopf, H; Dietrich, G; Kaufmann, SHE;
Indirizzi:
Max Planck Inst Infect Biol, Dept Immunol, D-10117 Berlin, Germany Max Planck Inst Infect Biol Berlin Germany D-10117 10117 Berlin, Germany Univ Wurzburg, Inst Hyg & Microbiol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 robiol, D-97080 Wurzburg, Germany
Titolo Testata:
BIOLOGICAL CHEMISTRY
fascicolo: 4, volume: 382, anno: 2001,
pagine: 521 - 532
SICI:
1431-6730(200104)382:4<521:IBATAC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYCOBACTERIUM-BOVIS BCG; CLASS-I PRESENTATION; T-CELL RESPONSES; RECOMBINANT SALMONELLA-TYPHIMURIUM; LEISHMANIA-MAJOR INFECTION; COLONY-STIMULATING FACTOR; TUBERCULOSIS DNA VACCINE; DIRECT GENE-TRANSFER; TOLL-LIKE RECEPTORS; SURFACE PROTEIN-A;
Keywords:
DNA vaccines; heterologous antigen expression; Mycobacterium tuberculosis; recombinant vaccine carrier strains; vaccine delivery;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
161
Recensione:
Indirizzi per estratti:
Indirizzo: Mollenkopf, H Max Planck Inst Infect Biol, Dept Immunol, Schumannstr 21-22, D-10117 Berlin, Germany Max Planck Inst Infect Biol Schumannstr 21-22 Berlin Germany D-10117
Citazione:
H. Mollenkopf et al., "Intracellular bacteria as targets and carriers for vaccination", BIOL CHEM, 382(4), 2001, pp. 521-532

Abstract

In this review we discuss intracellular bacteria as targets and carriers for vaccines. For clarity and ease of comprehension, we focus on three microbes, Mycobacterium tuberculosis, Listeria monocytogenes and Salmonella, with an emphasis on tuberculosis, one of the leading causes of death from infectious disease. Novel vaccination strategies against these pathogens are currently being considered. One approach favors the use of live attenuated vaccines and vaccine carrier strains thereof, either for heterologous antigenpresentation or DNA vaccine delivery. This strategy includes both the improvement of attenuated vaccine strains as well as the 'de novo' generation of attenuated variants of virulent pathogens. An alternative strategy relieson the application of subunit immunizations, either as nucleic acid vaccines or protein antigens of the pathogen. Finally, we present a short summaryof the vaccination strategies against tuberculosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 01:04:55