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Titolo:
Cloning, expression, and mapping of a mouse gene, Uchl4, highly homologousto human and mouse Uchl3
Autore:
Osawa, Y; Wang, YL; Osaka, H; Aoki, S; Wada, K;
Indirizzi:
Natl Inst Neurosci, Dept Degenerat Neurol Dis, Tokyo, Japan Natl Inst Neurosci Tokyo Japan Dept Degenerat Neurol Dis, Tokyo, Japan Natl Ctr Neurol & Psychiat, Natl Ctr Hosp Mental Nervous & Muscular Disorders, Tokyo 1878502, Japan Natl Ctr Neurol & Psychiat Tokyo Japan 1878502 ers, Tokyo 1878502, Japan Asahikawa Med Coll, Dept Anat, Asahikawa, Hokkaido 0788510, Japan Asahikawa Med Coll Asahikawa Hokkaido Japan 0788510 kkaido 0788510, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 3, volume: 283, anno: 2001,
pagine: 627 - 633
SICI:
0006-291X(20010511)283:3<627:CEAMOA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-TERMINAL HYDROLASES; DEUBIQUITINATING ENZYMES; PGP 9.5; PROTEIN; RAT; SPECIFICITY; ANTIBODIES; PGP-9.5;
Keywords:
ubiquitin; ubiquitin carboxyl terminal hydrolase (Uchl1, Uchl2, Uchl3, Uchl4);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Wada, K Natl Inst Neurosci, Dept Degenerat Neurol Dis, Tokyo, Japan Natl Inst Neurosci Tokyo Japan generat Neurol Dis, Tokyo, Japan
Citazione:
Y. Osawa et al., "Cloning, expression, and mapping of a mouse gene, Uchl4, highly homologousto human and mouse Uchl3", BIOC BIOP R, 283(3), 2001, pp. 627-633

Abstract

Ubiquitin carboxyl-terminal hydrolases (UCHs) are implicated in the proteolytic processing of polymeric ubiquitin, We have isolated a novel mouse gene for ubiquitin carboxyl-terminal hydrolase isozyme L4. The gene named Uchl4 encodes a novel member of the family of ubiquitin carboxyl-terminal hydrolases (UCHs) whose predicted amino acid sequence shows 95% identity to mouse UCH-L3 and 94% identity to human UCH-L3, Genomic structure, chromosome localization, and expression pattern of Uchl3 and Uchl4 were characterized inthe mouse. Both Uchl3 and Uchl4 were expressed in various tissues examined; however, expression level was quite lower in Uchl4. While Uchl3 consists of at least 9 exons spanning about 12 kb, Uchl4 was an intronless gene witha size of about 2 kb. By PCR-based analysis with T31 radiation hybrid mapping panel, Uchl3 and Uchl4 were mapped on mouse chromosome 9 and 14, respectively. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:08:04