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Titolo:
Physiology and pathophysiology of the calcium-sensing receptor.
Autore:
Houillier, P; Eladari, D; Maruani, G;
Indirizzi:
Hop Europeen Georges Pompidou, Dept Physiol & Radioisotopes, F-75015 Paris, France Hop Europeen Georges Pompidou Paris France F-75015 F-75015 Paris, France
Titolo Testata:
ARCHIVES DE PEDIATRIE
fascicolo: 5, volume: 8, anno: 2001,
pagine: 516 - 524
SICI:
0929-693X(200105)8:5<516:PAPOTC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
FRE
Soggetto:
FAMILIAL HYPOCALCIURIC HYPERCALCEMIA; NEONATAL SEVERE HYPERPARATHYROIDISM; AUTOSOMAL-DOMINANT HYPOCALCEMIA; EXTRACELLULAR CALCIUM; CA2+-SENSING RECEPTOR; SPORADIC HYPOPARATHYROIDISM; FUNCTIONAL EXPRESSION; BINDING DOMAIN; LIGAND-BINDING; MUTATIONS;
Keywords:
calcium-sensing receptor; hypocalcemia; hypercalcemia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Houillier, P Hop Europeen Georges Pompidou, Dept Physiol & Radioisotopes, 20-40 Rue Leblanc, F-75015 Paris, France Hop Europeen Georges Pompidou 20-40 Rue Leblanc Paris France F-75015
Citazione:
P. Houillier et al., "Physiology and pathophysiology of the calcium-sensing receptor.", ARCH PED, 8(5), 2001, pp. 516-524

Abstract

The near constancy of extracellular calcium concentration is required for the numerous physiological functions of extra- and intracellular calcium. This implies that any change in extracellular calcium concentration must be detected in order to allow the appropriate correction by the homeostatic systems. The identification and cloning of a calcium-sensing receptor (CaR), which is expressed in the plasma membrane of parathyroid cells as well as many other cell types, has been a major advance in the understanding of the mechanisms involved in the control of extracellular calcium concentration. In addition, it demonstrated that extracellular calcium concentration itself is the first informative hormonelike messenger in this system. CaR belongs to the C subfamily of seven transmembrane-spanning G protein-coupled receptors. Several inherited disorders in extracellular calcium homeostasis aredue to both activating or inactivating mutations in CaR gene, strenghthening the essential role of CaR in the control of calcium metabolism. (C) 2001Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:37:08