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Titolo:
Cognitive impairment in motor neuron disease with bulbar onset
Autore:
Portet, F; Cadilhac, C; Touchon, J; Camu, W;
Indirizzi:
Hop Gui Chauliac, Unite Neurol Comportementale & Degenerat, Serv Neurol B,F-34295 Montpellier 5, France Hop Gui Chauliac Montpellier France 5 ol B,F-34295 Montpellier 5, France
Titolo Testata:
AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS
fascicolo: 1, volume: 2, anno: 2001,
pagine: 23 - 29
SICI:
1466-0822(200103)2:1<23:CIIMND>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; APOLIPOPROTEIN-E EPSILON-4; CEREBRAL BLOOD-FLOW; FRONTOTEMPORAL DEMENTIA; ALZHEIMERS-DISEASE; DYSFUNCTION; ASSOCIATION; DIAGNOSIS; LATENCY; SPECT;
Keywords:
bulbar onset; ALS cognitive impairment; event related potentials; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Portet, F Hop Gui Chauliac, Unite Neurol Comportementale & Degenerat, ServNeurol B,80 Rue Auguste Fliche, F-34295 Montpellier 5, France Hop Gui Chauliac 80 Rue Auguste Fliche Montpellier France 5 nce
Citazione:
F. Portet et al., "Cognitive impairment in motor neuron disease with bulbar onset", AMYOTROPH L, 2(1), 2001, pp. 23-29

Abstract

METHODS: Twenty-three patients with bulbar onset motor neuron disease/amyotrophic lateral sclerosis (MND/ALS) were clinically assessed. They subsequently underwent serial neuropsychological testing, event-related potentials (ERP) and SPECT studies. Cognitive impairment was defined by clinical evidence of dementia (DSM-IV and frontal evaluation) or by significant alteration indicated by neuropsychological testing (excluding patients with depression and major anxiety), or both. RESULTS: Eleven patients (48%) were found to be cognitively impaired. Abnormalities indicated fronto-temporal involvement, with memory impairment, alteration of judgement and reasoning, reduced speech, behavioural dyscontroland alteration of daily living activities. This impairment correlated wellwith event-related potentials and SPECT studies. Event-related potentials were the most sensitive test as 100% of the impaired patients had abnormal ERP (p = 0.04). The cognitively impaired group differed from the other group mainly by gender ratio (male/female) with an important male predominance:1,75 vs. 0.33. MND/ALS was also more severe when decline was present. CONCLUSION: This study adds further arguments for a cognitive impairment in MND/ALS, This also reinforces the hypothesis that there is continuum between MND/ALS and fronto-temporal lobe dementia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:00:52