Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Examining the evidence about treatment in ALS/MND
Autore:
Miller, RG;
Indirizzi:
Calif Pacific Med Ctr, Dept Neurol, San Francisco, CA 94115 USA Calif Pacific Med Ctr San Francisco CA USA 94115 Francisco, CA 94115 USA
Titolo Testata:
AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS
fascicolo: 1, volume: 2, anno: 2001,
pagine: 3 - 7
SICI:
1466-0822(200103)2:1<3:ETEATI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; PATIENT-CARE DATABASE; RILUZOLE; ALS;
Keywords:
amyotrophic lateral sclerosis (ALS); clinical trials; evidence-based medicine; guidelines; motor neuron disease; practice parameters; riluzole;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, RG Calif Pacific Med Ctr, Dept Neurol, 2324 Sacramento St,150, SanFrancisco,CA 94115 USA Calif Pacific Med Ctr 2324 Sacramento St,150 San Francisco CA USA 94115
Citazione:
R.G. Miller, "Examining the evidence about treatment in ALS/MND", AMYOTROPH L, 2(1), 2001, pp. 3-7

Abstract

The application of evidence-based medicine to the treatment of patients with amyotrophic lateral sclerosis (ALS) is just beginning. A small number ofsystematic reviews analyzing the pertinent evidence, grading the methodology and formulating recommendations to guide clinical decision-making have begun to appear. The American Academy of Neurology practice parameters for informing the patient and managing nutritional and respiratory issues and palliative care are discussed. In addition, the first systematic review in the field of ALS/MND from the Cochrane collaboration concerns riluzole treatment and this meta-analysis is also described. Some of the most important recommendations that have the potential to significantly prolong survival andenhance quality of life are the early institution of percutaneous endoscopic gastrostomy for patients with significant dysphagia, and the initiation of non-invasive positive pressure ventilation for patients with symptoms ofearly respiratory insufficiency. Assertive treatment of pain and dyspnea are also strongly recommended for patients with ALS. The North American ALS patient database, ALS C.A.R.E., is also described as a methodology for measuring clinical outcomes, and some early results are presented. The evidenceon riluzole indicates effectiveness in prolonging survival with a good safety profile.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:30:04