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Titolo:
Motoneuron cell death and neurotrophic factors: Basic models for development of new therapeutic strategies in ALS
Autore:
Beck, M; Karch, C; Wiese, S; Sendtner, M;
Indirizzi:
Inst Clin Neurobiol, D-97080 Wurzburg, Germany Inst Clin Neurobiol Wurzburg Germany D-97080 , D-97080 Wurzburg, Germany
Titolo Testata:
AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS
, volume: 2, anno: 2001, supplemento:, 1
pagine: S55 - S68
SICI:
1466-0822(200103)2:<S55:MCDANF>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE-GROWTH-FACTOR; AMYOTROPHIC-LATERAL-SCLEROSIS; TROPHIC FACTOR DEPRIVATION; SPINAL MUSCULAR-ATROPHY; MOTOR-NEURON DISEASE; NF-KAPPA-B; FACTOR-RECEPTOR; PROTEIN-KINASE; CHICK-EMBRYO; PC12 CELLS;
Keywords:
motor neuron; apoptosis; neutrophic factors; CAMP; laminin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
134
Recensione:
Indirizzi per estratti:
Indirizzo: Sendtner, M Inst Clin Neurobiol, Josef Schneider Str 11, D-97080 Wurzburg,Germany Inst Clin Neurobiol Josef Schneider Str 11 Wurzburg Germany D-97080
Citazione:
M. Beck et al., "Motoneuron cell death and neurotrophic factors: Basic models for development of new therapeutic strategies in ALS", AMYOTROPH L, 2, 2001, pp. S55-S68

Abstract

Motoneurons are generated in excess during embryonic development of highervertebrates. In the lumbar spinal cord of the developing rat, about 6000 motoneurons are present at embryonic day 14. These neurons grow out axons which make contact with their target tissue, the skeletal muscle, About 50% of the motoneurons are lost during a critical period from embryonic day 14 until postnatal day 3. This process, which is called physiological motoneuron cell death, has been the focus of research aiming at the identification of neurotrophic factors which regulate motoneuron during this developmental Motoneuron cell death can also be observed in vitro when the motoneurons are isolated from the embryonic avian or factors survival period. rodent spinal cord. These isolated motoneurons and other types of primary have been a useful tool for studying basic mechanisms underlying neuronal degeneration during development and under pathophysiological conditions in neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS). Accumulating evidence from such studies suggests that some specific requirements of motoneurons for survival and proper function may change during development. Thesefindings might be relevant for understanding the pathophysiological processes underlying ALS and thus could contribute to the development of new therapeutic strategies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:15:50