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Titolo:
Clinical trials: the past, a lesson for the future
Autore:
Meininger, V;
Indirizzi:
Hop La Pitie Salpetriere, Div Mazarin, F-75651 Paris 13, France Hop La Pitie Salpetriere Paris France 13 zarin, F-75651 Paris 13, France
Titolo Testata:
AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS
, volume: 2, anno: 2001, supplemento:, 1
pagine: S15 - S18
SICI:
1466-0822(200103)2:<S15:CTTPAL>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; PLACEBO-CONTROLLED TRIAL; THYROTROPIN-RELEASING-HORMONE; BLIND CONTROLLED TRIAL; PILOT TRIAL; L-THREONINE; IMMUNOSUPPRESSION; DEXTROMETHORPHAN; THERAPY; ALS;
Keywords:
amyotrophic lateral sclerosis; clinical trials; excitotoxicity; growth factors; riluzole;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Meininger, V Hop La Pitie Salpetriere, Div Mazarin, 47 Blvd Hop, F-75651 Paris 13, France Hop La Pitie Salpetriere 47 Blvd Hop Paris France 13 France
Citazione:
V. Meininger, "Clinical trials: the past, a lesson for the future", AMYOTROPH L, 2, 2001, pp. S15-S18

Abstract

Numerous drugs have been tested in amyotrophic lateral sclerosis with the expectations both that they will treat patients and improve our understanding of some of the basic mechanisms of the disease. Most of these trials were considered to be negative. Careful analysis of the trials does not allow us to clearly discard any of the tested drugs, or any of the suspected mechanisms. Expectations for the future are that: a) we need to be realistic about what to expect; b) we have to define clearly our end-points; c) we haveto calculate the expected power before the trials, not after; and d) we have to improve our understanding of the pharmacology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:20:12