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Titolo:
ALS 2000: the past points to the future
Autore:
Swash, M;
Indirizzi:
Royal London Hosp, Dept Neurol, London E1 1BB, England Royal London Hosp London England E1 1BB t Neurol, London E1 1BB, England
Titolo Testata:
AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS
, volume: 2, anno: 2001, supplemento:, 1
pagine: S3 - S9
SICI:
1466-0822(200103)2:<S3:A2TPPT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; MOTOR-NEURON DISEASE; CLASSIFICATION; CONDUCTION; TRANSPORT; MUTATION; EXPRESS; MICE;
Keywords:
amyotrophic lateral sclerosis; diagnosis; pathogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Swash, M Royal London Hosp, Dept Neurol, London E1 1BB, England Royal London Hosp London England E1 1BB London E1 1BB, England
Citazione:
M. Swash, "ALS 2000: the past points to the future", AMYOTROPH L, 2, 2001, pp. S3-S9

Abstract

In this introductory review a number of issues concerning the direction offuture research in ALS are addressed in relation to current understanding of this disorder and its treatment. The importance of understanding the pathways leading to motor neuron dysfunction and death is emphasized. Contemporary epidemiology, understandably focussed on genetic markers for familiar ALs, needs to be widened to include as yet undocumented susceptibility- related genetic traits. Potential avenues for therapy are considered, and the fundamental contemporary issue of clinical measurement is discussed, Neglected aspects of contemporary research, including disturbed axoplasmic flow, are brought to attention. The role of experiment derived from clinical observation, and vice versa, is described by reference to a number of past and recent contributions to the understanding of ALs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 16:32:26