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Titolo:
Metabolic and structural abnormalities in dogs with early left ventriculardysfunction induced by incessant tachycardia
Autore:
Mc Entee, K; Flandre, T; Dessy, C; Desmecht, D; Clercx, C; Balligand, M; Michaux, C; Jonville, E; Miserque, N; Henroteaux, M; Keene, B;
Indirizzi:
Univ Liege, Dept Small Anim Clin Sci, Fac Med Vet, B-4000 Liege, Belgium Univ Liege Liege Belgium B-4000 Sci, Fac Med Vet, B-4000 Liege, Belgium Univ Liege, Dept Histol Domest Anim, Fac Med Vet, B-4000 Liege, Belgium Univ Liege Liege Belgium B-4000 Anim, Fac Med Vet, B-4000 Liege, Belgium Univ Liege, Dept Pathol Domest Anim, Fac Med Vet, B-4000 Liege, Belgium Univ Liege Liege Belgium B-4000 Anim, Fac Med Vet, B-4000 Liege, Belgium Univ Liege, Dept Genet, Fac Med Vet, B-4000 Liege, Belgium Univ Liege Liege Belgium B-4000 enet, Fac Med Vet, B-4000 Liege, Belgium N Carolina State Univ, Coll Vet Med, Dept Med Sci, Raleigh, NC 27606 USA NCarolina State Univ Raleigh NC USA 27606 Med Sci, Raleigh, NC 27606 USA
Titolo Testata:
AMERICAN JOURNAL OF VETERINARY RESEARCH
fascicolo: 6, volume: 62, anno: 2001,
pagine: 889 - 894
SICI:
0002-9645(200106)62:6<889:MASAID>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; MYOCARDIAL CARNITINE METABOLISM; CANINE MODEL; END-STAGE; CARDIOMYOPATHY; TISSUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Mc Entee, K Univ Liege, Dept Small Anim Clin Sci, Fac Med Vet, B-4000 Liege, Belgium Univ Liege Liege Belgium B-4000 d Vet, B-4000 Liege, Belgium
Citazione:
K. Mc Entee et al., "Metabolic and structural abnormalities in dogs with early left ventriculardysfunction induced by incessant tachycardia", AM J VET RE, 62(6), 2001, pp. 889-894

Abstract

Objective-To assess morphologic and metabolic abnormalities in dogs with early left ventricular dysfunction (ELVD) induced by rapid right ventricularpacing (RRVP). Animals-7 Beagles. Procedure-Plasma carnitine concentrations were measured before and after development of ELVD induced by RRVP. At the same times, transvenous endomyocardial biopsy was performed, and specimens were submitted for determinationof myocardial carnitine concentrations and histologic, morphometric, and ultrastructural examination. Results-In 4 dogs in which baseline plasma total carnitine concentration was normal, RRVP induced a decrease in myocardial total and free carnitine concentrations and an increase in myocardial esterified carnitine concentration. In 3 dogs in which baseline plasma total carnitine concentration was low, plasma and myocardial carnitine concentrations were unchanged after pacing. Structural changes associated with pacing included perinuclear vacuolization in 3 dogs. Morphometric analyses indicated there was a decrease in myofiber cross-sectional diameter and area following pacing. Electron microscopy revealed changes in myofibrils and mitochondria following pacing. Conclusions and Clinical Relevance Results indicated that moderate to severe alterations in myocyte cytoarchitecture are present in dogs with ELVD induced by RRVP and that in dogs with normal plasma carnitine concentrations,myocardial carnitine deficiency may be a biochemical marker of ELVD. Results also indicated that transvenous endomyocardial biopsy can be used to evaluate biochemical and structural myocardial changes in dogs with cardiac disease.

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Documento generato il 04/04/20 alle ore 01:51:32