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Titolo:
Short report: Failure to select for chloroquine- or mefloquine-resistant Plasmodium berghei through drug pressure in Anopheles stephensi mosquitoes
Autore:
Coleman, RE; Song, GH; Wirtz, RA;
Indirizzi:
Armed Forces Res Inst Med Sci, Dept Entomol, USA Med Component, Bangkok 10400, Thailand Armed Forces Res Inst Med Sci Bangkok Thailand 10400 kok 10400, Thailand Ctr Dis Control & Prevent, Entomol Branch, Atlanta, GA 30341 USA Ctr Dis Control & Prevent Atlanta GA USA 30341 nch, Atlanta, GA 30341 USA Shanghai Mil Med Univ, Dept Parasitol, Shanghai, Peoples R China Shanghai Mil Med Univ Shanghai Peoples R China hanghai, Peoples R China
Titolo Testata:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
fascicolo: 3-4, volume: 63, anno: 2000,
pagine: 119 - 120
SICI:
0002-9637(200009/10)63:3-4<119:SRFTSF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
FALCIPARUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Coleman, RE Armed Forces Res Inst Med Sci, Dept Entomol, USA Med Component, 315-6 Rajvithi Rd, Bangkok 10400, Thailand Armed Forces Res Inst Med Sci 315-6 Rajvithi Rd Bangkok Thailand 10400
Citazione:
R.E. Coleman et al., "Short report: Failure to select for chloroquine- or mefloquine-resistant Plasmodium berghei through drug pressure in Anopheles stephensi mosquitoes", AM J TROP M, 63(3-4), 2000, pp. 119-120

Abstract

We investigated whether chloroquine- or mefloquine-resistant Plasmodium berghei could be selected through drug pressure applied during continuous cyclical transmission in Anopheles stephensi mosquitoes. Mosquitoes were infected by feeding them on mice previously inoculated with a drug-sensitive clone of P. berghei ANKA. Mosquitoes ingested mefloquine or chloroquine with the infectious blood-meal, or by feeding on a drug-treated (uninfected) mouse 4 or 10 days after the infectious blood-meal. Twenty-two days after beinginfected, mosquitoes transmitted sporozoites to uninfected mice. Blood from these animals was used to infect naive mice that were then used to reinitiate the mouse/mosquito/mouse cycle. A total of 20 passages through mosquitoes were completed while under drug pressure:. Drug-resistance levels were assessed in the initial clone and after 20 passages through mosquitoes. None of 18 "sub-clones" of parasites showed significant increases in chloroquine or mefloquine resistance, suggesting that exposure of sporogonic stage Plasmodium to chloroquine or mefloquine will not result in the development of drug resistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 15:27:36