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Titolo:
Breakthrough adverse reactions to low-osmolar contrast media after steroidpremedication
Autore:
Freed, KS; Leder, RA; Alexander, C; DeLong, DM; Kliewer, MA;
Indirizzi:
Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Radiol, Durham, NC 27710 USA
Titolo Testata:
AMERICAN JOURNAL OF ROENTGENOLOGY
fascicolo: 6, volume: 176, anno: 2001,
pagine: 1389 - 1392
SICI:
0361-803X(200106)176:6<1389:BARTLC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-RISK PATIENTS; ANAPHYLACTOID REACTIONS; RADIOCONTRAST MATERIAL; SELECTIVE USE; AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Leder, RA Duke Univ, Med Ctr, Dept Radiol, Box 3808, Durham, NC 27710 USA Duke Univ Box 3808 Durham NC USA 27710 808, Durham, NC 27710 USA
Citazione:
K.S. Freed et al., "Breakthrough adverse reactions to low-osmolar contrast media after steroidpremedication", AM J ROENTG, 176(6), 2001, pp. 1389-1392

Abstract

OBJECTIVE. The purpose of this study was to review the nature of adverse reactions, or "breakthrough reactions," experienced by patients who receivedsteroid premedication and low-osmolar contrast media. We compared the demographics of patients having these breakthrough reactions with those of patients who did not develop these reactions. MATERIALS AND METHODS. We retrospectively reviewed our radiology quality improvement database to identify patients with breakthrough reactions that occurred from January 1, 1994, through October 1, 1999, and we reviewed their medical records. We compared these patients with a control cohort of patients who had a history of prior adverse reaction to contrast media but no breakthrough reaction after administration of low-osmolar contrast media andpremedication with corticosteroids. RESULTS. Over the 6-year period, 52 patients experienced 61 breakthrough reactions. The breakthrough reaction was mild in 76% of the patients. The breakthrough reaction was similar to the patient's initial adverse reaction in 85% of the patients. A history of seafood allergy or hay fever was statistically more likely to be identified in the breakthrough group than the control group. CONCLUSION. Breakthrough reactions occur in a substantial number of patients despite premedication with steroids and use of low-osmolar contrast agents. Typically the breakthrough reaction is of similar severity to the patient's initial reaction. Severe or life-threatening reactions are seen in 24%of patients.

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Documento generato il 18/01/21 alle ore 16:31:42