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Titolo:
Alveolar macrophages that phagocytose apoptotic neutrophils produce hepatocyte growth factor during bacterial pneumonia in mice
Autore:
Morimoto, K; Amano, H; Sonoda, F; Baba, M; Senba, M; Yoshimine, H; Yamamoto, H; Ii, T; Oishi, K; Nagatake, T;
Indirizzi:
Nijigaoka Hosp, Dept Resp Med, Nagasaki 8528055, Japan Nijigaoka Hosp Nagasaki Japan 8528055 Resp Med, Nagasaki 8528055, Japan Nijigaoka Hosp, Dept Metab Dis, Nagasaki 8528055, Japan Nijigaoka Hosp Nagasaki Japan 8528055 Metab Dis, Nagasaki 8528055, Japan Nagasaki Univ, Inst Trop Med, Nagasaki 852, Japan Nagasaki Univ NagasakiJapan 852 niv, Inst Trop Med, Nagasaki 852, Japan Nagasaki Univ, Dept Internal Med, Nagasaki 852, Japan Nagasaki Univ Nagasaki Japan 852 Dept Internal Med, Nagasaki 852, Japan Nagasaki Univ, Dept Pathol, Nagasaki 852, Japan Nagasaki Univ Nagasaki Japan 852 Univ, Dept Pathol, Nagasaki 852, Japan
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
fascicolo: 5, volume: 24, anno: 2001,
pagine: 608 - 615
SICI:
1044-1549(200105)24:5<608:AMTPAN>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLS IN-VITRO; II CELLS; LUNG INJURY; PULMONARY INFLAMMATION; VITRONECTIN RECEPTOR; DNA-SYNTHESIS; EXPRESSION; RESOLUTION; RECOGNITION; PROLIFERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Morimoto, K Nijigaoka Hosp, Dept Resp Med, 1-1 Nijigaoka, Nagasaki 8528055, Japan Nijigaoka Hosp 1-1 Nijigaoka Nagasaki Japan 8528055 55, Japan
Citazione:
K. Morimoto et al., "Alveolar macrophages that phagocytose apoptotic neutrophils produce hepatocyte growth factor during bacterial pneumonia in mice", AM J RESP C, 24(5), 2001, pp. 608-615

Abstract

Hepatocyte growth factor (HGF) is postulated to play an important role in the repair of pulmonary epithelium in acute lung injury. To evaluate the role of HGF in bacterial pneumonia, the kinetics of HGF production and the cellular sources of HGF have been examined in the lungs of mice that had beenintratracheally challenged with Pseudomonas aeruginosa. Neutrophil accumulation in the airway occurred immediately, reached a peak at 36 h, and then progressively declined by 14 d after infection. We found a biphasic patternof HGF messenger RNA expression and protein synthesis in the lung after bacterial infection. The first peak for HGF production was found at 6 h afterinfection, and the primary source of HGF was shown to be bronchial epithelial cells. Interestingly, the second peak;for HGF production, which was found around 48 to 72 h after infection, was closely associated with the increase in the percentage of alveolar macrophages (AMs) that became positive for myeloperoxidase, indicating phagocytosis of apoptotic neutrophils. The cellular source of the second peak was found to be AMs. Further, murine AMs which phagocytosed apoptotic neutrophils induced higher levels of HGF production in vitro. These results strongly indicate a novel mechanism of HGF production by AMs, which are phagocytosing apoptotic neutrophils, and the pivotal role of AMs in the healing and repair of damaged pulmonary epithelium through the production of HGF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:32:24