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Titolo:
Association of asthma with beta(2)-adrenergic receptor gene polymorphism and cigarette smoking
Autore:
Wang, ZX; Chen, CZ; Niu, TH; Wu, D; Yang, JH; Wang, BY; Fang, Z; Yandava, CN; Drazen, JM; Weiss, ST; Xu, XP;
Indirizzi:
Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 gram Populat Genet, Boston, MA 02115 USA Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Pulm, Boston, MA USA Harvard Univ Boston MA USA igham & Womens Hosp, Div Pulm, Boston, MA USA Harvard Univ, Sch Med, Dept Med, Channing Lab, Boston, MA USA Harvard Univ Boston MA USA h Med, Dept Med, Channing Lab, Boston, MA USA Anhui Meizhong Inst Biomed Sci & Environm Hlth, Anqing, Peoples R China Anhui Meizhong Inst Biomed Sci & Environm Hlth Anqing Peoples R China a Anhui Med Univ, Inst Biomed, Hefei, Peoples R China Anhui Med Univ HefeiPeoples R China nst Biomed, Hefei, Peoples R China Beijing Med Univ, Ctr Ecogenet & Reprod Hlth, Beijing, Peoples R China Beijing Med Univ Beijing Peoples R China Hlth, Beijing, Peoples R China Anqing Publ Hlth Bur, Anqing, Peoples R China Anqing Publ Hlth Bur Anqing Peoples R China ur, Anqing, Peoples R China
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 6, volume: 163, anno: 2001,
pagine: 1404 - 1409
SICI:
1073-449X(200105)163:6<1404:AOAWBR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSPECIFIC BRONCHIAL RESPONSIVENESS; BETA-ADRENERGIC RECEPTORS; PULMONARY-FUNCTION; BETA-2-ADRENERGIC RECEPTOR; POPULATION-SAMPLE; PASSIVE SMOKING; CHILDREN; SMOKERS; LOCI; SUSCEPTIBILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Xu, XP Harvard Univ, Sch Publ Hlth, Program Populat Genet, 665 Huntington Ave,FXB-101, Boston, MA 02115 USA Harvard Univ 665 Huntington Ave,FXB-101 Boston MA USA 02115 115 USA
Citazione:
Z.X. Wang et al., "Association of asthma with beta(2)-adrenergic receptor gene polymorphism and cigarette smoking", AM J R CRIT, 163(6), 2001, pp. 1404-1409

Abstract

Recent studies have suggested that two polymorphisms of the beta (2)-adrenergic receptor (beta (2)AR) gene at codons 16 (arginine to glycine) and 27 (glutamine to glutamate) affect an individual's airway responsiveness, or response to acute or chronic beta (2)-agonist therapy but are not risk factors for asthma. We hypothesize that there is an interaction effect on asthmabetween the beta (2)AR gene polymorphisms and cigarette smoking. A case-control study was conducted in 128 asthma cases and 136 control individuals identified from 10,014 studied subjects in rural Anqing, China. Allele-specific polymerase chain reaction (PCR) was used to genotype beta (2)AR gene polymorphisms. Multiple logistic regression was used to adjust for potential confounding factors. We found a marginally significant interaction between cigarette smoking and beta (2)AR-16 genotype after adjusting for important confounding factors (p = 0.06). Specifically, we found that compared with never-smoking Gry-16 homozygotes, those ever-smokers who are Arg-16 homozygotes had a significantly increased risk of asthma (odds ratio [OR] = 7.81; 95% confidence interval [CI]: 2.07 to 29.5). This association showed a cleardose-response relationship with the number of cigarettes smoked. However, there was no significant association of asthma with polymorphisms of the beta (2)AR at position 27 (OR = 1.38; 95% CI: 0.69 to 2.73). Our study suggests a gene-environment interaction between the Arg-16 genotype and ever cigarette smoking with respect to the susceptibility of an individual to asthma.

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Documento generato il 26/02/20 alle ore 06:18:02