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Titolo:
Quality-adjusted survival in the first year after the acute respiratory distress syndrome
Autore:
Angus, DC; Musthafa, AA; Clermont, G; Griffin, MF; Linde-Zwirble, WT; Dremsizov, TT; Pinsky, MR;
Indirizzi:
Univ Pittsburgh, Dept Anesthesiol & Crit Care Med, Crit Care Med Div, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 Med Div, Pittsburgh, PA 15213 USA Univ Pittsburgh, Ctr Res Hlth Care, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 th Care, Pittsburgh, PA 15213 USA Redding Crit Care Med Grp, Redding, CA USA Redding Crit Care Med Grp Redding CA USA t Care Med Grp, Redding, CA USA Hlth Proc Management Inc, Doylestown, PA USA Hlth Proc Management Inc Doylestown PA USA ement Inc, Doylestown, PA USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 6, volume: 163, anno: 2001,
pagine: 1389 - 1394
SICI:
1073-449X(200105)163:6<1389:QSITFY>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; WELL-BEING SCALE; COST-EFFECTIVENESS; OF-LIFE; VENTILATION STRATEGY; CYSTIC-FIBROSIS; CRITICALLY ILL; HEALTH; CARE; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Angus, DC Univ Pittsburgh, Dept Anesthesiol & Crit Care Med, Crit Care MedDiv, Room604 Scaife Hall,200 Lothrop St, Pittsburgh, PA 15213 USA Univ Pittsburgh Room 604 Scaife Hall,200 Lothrop St Pittsburgh PA USA 15213
Citazione:
D.C. Angus et al., "Quality-adjusted survival in the first year after the acute respiratory distress syndrome", AM J R CRIT, 163(6), 2001, pp. 1389-1394

Abstract

There is little information on long-term outcome after acute respiratory distress syndrome (ARDS). We measured quality-adjusted survival in the firstyear after ARDS in a prospective cohort (n = 200). All patients met traditional criteria for ARDS. Patients with sepsis and acute nonpulmonary organ dysfunction at presentation were excluded. The cohort was healthy before onset of ARDS as evidenced by high functional status (mean Karnofsky Performance Status index: 82.2/100 where greater than or equal to 80 = able to perform normal activities independently) and minimal comorbid illness (mean Charlson-Deyo comorbidity score: 0.32/17 where 0 = absence of chronic illness). We determined quality-adjusted life-years (QALYs) using the Quality of Well-being (QWB) scale (0 to 1 scale where 1 = optimal well-being), measured at 6 and 12 mo. Survival was 69.5 +/- 5.0% at 1 month, fell to 55.7 +/- 3.7% at 6 mo, and did not change at 12 mo, yielding a survival of 59 life-years in the first year per 100 patients with ARDS. QWB was low at 6 and 12 mo (0.59 +/- 0.015 and 0.60 +/- 0.015), yielding a quality-adjusted survival of 36 QALYs per 100 patients (sensitivity range: 21 to 46 QALYs). We conclude that ARDS developing in previously healthy patients is associated with poor quality-adjusted survival. These data are important for cost-effectiveness analyses and long-term care.

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Documento generato il 26/01/20 alle ore 00:59:28