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Titolo:
Unique susceptibility of the fetal thymus to feline immunodeficiency virusinfection: An animal model for HIV infection in utero
Autore:
Johnson, CM; Bortnick, SJ; Crawford, PC; Papadi, GP;
Indirizzi:
Univ Florida, Coll Vet Med, Dept Pathobiol, Div Comparat Med, Gainesville,FL 32610 USA Univ Florida Gainesville FL USA 32610 parat Med, Gainesville,FL 32610 USA
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 5, volume: 45, anno: 2001,
pagine: 273 - 288
SICI:
1046-7408(200105)45:5<273:USOTFT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL HOMEOSTASIS; SELECTIVE THYMOCYTE DEPLETION; DOMESTIC CATS; LYMPHOCYTE SUBSETS; IN-VIVO; MONOCLONAL-ANTIBODIES; IMMUNE DYSFUNCTION; AIDS PATHOGENESIS; INTERFERON-GAMMA; JUVENILE CATS;
Keywords:
thymus gland; HIV; fetus; immunodeficiency virus; feline;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
92
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, CM Univ Florida, Coll Vet Med, Dept Pathobiol, POB 110880, Gainesville, FL 32611 USA Univ Florida POB 110880 Gainesville FL USA 32611 FL 32611 USA
Citazione:
C.M. Johnson et al., "Unique susceptibility of the fetal thymus to feline immunodeficiency virusinfection: An animal model for HIV infection in utero", AM J REPROD, 45(5), 2001, pp. 273-288

Abstract

PROBLEM: Human infants infected in utero with HIV develop thymus insufficiency and progress to AIDS sooner than infants infected peripartum. However,dir;ect analysis of the thymus is difficult due to limited tissue access and variable timing of vertical transmission. METHOD OF STUDY: Fetal and neonatal cats were inoculated with feline immunodeficiency virus (FIV) at an equivalent infectious dose. The thymus, blood, and lymph nodes were harvested and compared at 23 and 46 days post-inoculation (p.i.) and also compared to sham-inoculated, age-matched controls. Lymphocyte phenotypes were analyzed by flow cytometry and virus burden was quantified in histologic sections and by virus isolation from plasma. RESULTS: Fetal cats inoculated with FIV had acute thymus atrophy at birth,which coincided with peak viremia. At 46 days p.i., thymus size and cell composition rebounded and supported increased productive infection. In contrast, neonatal cats inoculated with FIV developed chronic thymus atrophy anddegeneration, which was associated with decreasing productive infection and low-level viremia. CONCLUSIONS: The fetal thymus is uniquely vulnerable to acute, transient depletion and high-level productive infection. The neonatal thymus is less vulnerable to acute changes, and responds through progressive atrophy and declining productive infection. Reduced immune competence, as reflected by the failure to control virus replication, may contribute to the accelerated progression of FIV and HIV infections in utero.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:46:01