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Titolo:
DNA ploidy and cyclin D1 expression in basal cell carcinoma of the head and neck
Autore:
Staibano, S; Muzio, LL; Pannone, G; Mezza, E; Argenziano, G; Vetrani, A; Lucariello, A; Franco, R; Errico, ME; De Rosa, G;
Indirizzi:
Univ Naples Federico II, Fac Med & Surg, Dept Biomorphol & Funct Sci, Pathol Sect, Naples, Italy Univ Naples Federico II Naples Italy ct Sci, Pathol Sect, Naples, Italy Univ Naples Federico II, Fac Med & Surg, Dept Dermatol, Div Cutaneous Precancerosis, Naples, Italy Univ Naples Federico II Naples Italy neous Precancerosis, Naples, Italy Univ Naples Federico II, Fac Med & Surg, Dept Med 3, Div Cutaneous Precancerosis, Naples, Italy Univ Naples Federico II Naples Italy neous Precancerosis, Naples, Italy Univ Ancona, Inst Dent Sci, Fac Med & Surg, Ancona, Italy Univ Ancona Ancona Italy , Inst Dent Sci, Fac Med & Surg, Ancona, Italy
Titolo Testata:
AJCP. American journal of clinical pathology
fascicolo: 6, volume: 115, anno: 2001,
pagine: 805 - 813
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOLAR ORGANIZER REGIONS; BREAST-CANCER; PROGNOSTIC-SIGNIFICANCE; MALIGNANT LESIONS; DEPENDENT KINASES; IMAGE CYTOMETRY; FLOW-CYTOMETRY; SKIN; AMPLIFICATION; PATTERN;
Keywords:
cyclin D1; DNA ploidy; epiluminescence microscopy; basal cell carcinoma; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Staibano, S Via A Falcone 56, I-80127 Naples, Italy Via A Falcone 56 Naples Italy I-80127 I-80127 Naples, Italy
Citazione:
S. Staibano et al., "DNA ploidy and cyclin D1 expression in basal cell carcinoma of the head and neck", AM J CLIN P, 115(6), 2001, pp. 805-813

Abstract

Basal cell carcinomas (BCCs) may be subdivided into primary, with a favorable biologic course (BCC1) and recurrent and/or metastatic (BCC2), No clearassociation between primary tumor location, histologic subtype, or other clinicopathologic variables and predisposition for BCC2 has been found. Histopathologic criteria are limited for prognostication. To identify prognostic factors useful for planning therapy, we studied cyclin DJ immunohistochemical expression, DNA ploidy, and epiluminescence light microscopic (ELM) patterns in 60 cases of BCC (30 BCC1 and 30 BCC2) in the head and neck region, half of which were hyperpigmented. Cyclin DI was absent in 27 cases, expressed at low level in 4 cases, and overexpressed in 30 cases. Seven BCCs were euploid, 28 exhibited a mired cellular population,and 25 were aneuploid. Among aneuploid tumors, hypodiploidy was found in 12. Among the 30 pigmented carcinomas, only 15 showed a typical ELM pattern. No association between pigmentation and more aggressive biologic behavior of BCC was found. These results and follow-up data seem to indicate that an unfavorable outcome can be predicted bl hyperexpression of cyclin DI, aneuploidy, and an atypical ELM pattern for pigmented cases. A definite hypodiploid peak was associated with worse prognosis. The analysis of cyclin DI expression and DNA ploidy may help identify, BCC with an aggressive phenotype and a poor clinical outcome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 03:19:12