Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Probiotics in human disease
Autore:
Isolauri, E;
Indirizzi:
Univ Turku, Dept Pediat, Turku 20520, Finland Univ Turku Turku Finland 20520 Turku, Dept Pediat, Turku 20520, Finland
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 6, volume: 73, anno: 2001,
pagine: 1142S - 1146S
SICI:
0002-9165(200106)73:6<1142S:PIHD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LACTIC-ACID BACTERIA; GG-DERIVED ENZYMES; LACTOBACILLUS GG; ORAL BACTERIOTHERAPY; IMMUNE-RESPONSE; SUCKLING RATS; FOOD ALLERGY; DIARRHEA; GUT; TOLERANCE;
Keywords:
atopy; diarrhea; food allergy; gastrointestinal tract; infant; inflammation; probiotics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Isolauri, E Univ Turku, Dept Pediat, Turku 20520, Finland Univ Turku Turku Finland 20520 Pediat, Turku 20520, Finland
Citazione:
E. Isolauri, "Probiotics in human disease", AM J CLIN N, 73(6), 2001, pp. 1142S-1146S

Abstract

Western civilization is facing a progressive increase in immune-mediated, gut-related health problems, such as allergies and autoimmune and inflammatory diseases, and genetic factors are an unlikely explanation for these rapid increases in disease incidence. Two environmental factors that relate tothe modern Lifestyle in Western societies are hygiene and nutrition. Therehas been a decline in the incidence of microbial stimulation by infectiousdiseases as a result of improved hygiene, vaccination, and antimicrobial medication. In the past, methods of food preservation involved either the natural fermentation or drying of foods; thus, the human diet once contained several thousand times more bacteria than it does today. The development ofprobiotic, functional foods aims to "kill two birds with one stone," whichis accomplished by providing a microbial stimulus to the host immune system by means of beneficial live microorganism cultures that are characteristic of the healthy, human gut microflora, ie, probiotics. Probiotic bacteria were shown to reinforce the different lines of gut defense, which are immune exclusion, immune elimination, and immune regulation. They were also shown to stimulate nonspecific host resistance to microbial pathogens, thereby aiding in pathogen eradication. Consequently, the best documented clinical application of probiotics is in the treatment of acute diarrhea. In humans,documented effects were reported for the alleviation of intestinal inflammation, normalization of gut mucosal dysfunction, and down-regulation of hypersensitivity reactions. These data show that probiotics promote endogenoushost defense mechanisms. Thus, modification of gut microflora by probiotictherapy may offer a therapeutic potential in clinical conditions associated with gut-barrier dysfunction and inflammatory response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 08:53:05