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Titolo:
Association between B vitamin intake and plasma homocysteine concentrationin the general Dutch population aged 20-65 y
Autore:
de Bree, A; Verschuren, WMM; Blom, HJ; Kromhout, D;
Indirizzi:
Natl Inst Publ Hlth & Environm, Dept Chron Dis Epidemiol, NL-3720 BA Bilthoven, Netherlands Natl Inst Publ Hlth & Environm Bilthoven Netherlands NL-3720 BA herlands Univ Nijmegen, St Radboud Hosp, Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands Radboud Hosp, Nijmegen, Netherlands Univ Nijmegen Hosp, Lab Pediat & Neurol, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Hosp Nijmegen Netherlands NL-6500 HB Nijmegen, Netherlands
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 6, volume: 73, anno: 2001,
pagine: 1027 - 1033
SICI:
0002-9165(200106)73:6<1027:ABBVIA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLIC-ACID; RISK FACTOR; HORDALAND HOMOCYSTEINE; METHIONINE METABOLISM; COFFEE CONSUMPTION; VASCULAR-DISEASE; DIETARY-FOLATE; HYPERHOMOCYSTEINEMIA; ATHEROSCLEROSIS; DECREASES;
Keywords:
folate; riboflavin; vitamin B-6; vitamin B-12; plasma homocysteine; population-based study; Netherlands;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: de Bree, A Natl Inst Publ Hlth & Environm, Dept Chron Dis Epidemiol, CZE POB 1, NL-3720 BA Bilthoven, Netherlands Natl Inst Publ Hlth & Environm CZE POB 1 Bilthoven Netherlands NL-3720 BA
Citazione:
A. de Bree et al., "Association between B vitamin intake and plasma homocysteine concentrationin the general Dutch population aged 20-65 y", AM J CLIN N, 73(6), 2001, pp. 1027-1033

Abstract

Background: An elevated plasma total homocysteine (tHcy) concentration is associated with an increased risk of cardiovascular diseases. Folate, riboflavin, vitamin B-6, and vitamin B-12 are essential in homocysteine metabolismObjective: The objective was to describe the association between dietary intakes of folate, riboflavin, vitamin B-6, and vitamin B-12 and the nonfasting plasma tHcy concentration. Design: A random sample of 2435 men and women aged 20-65 y from a population-based Dutch cohort examined in 1993-1996 was analyzed cross-sectionally. Results: Univariately, intakes of all B vitamins were inversely related tothe plasma tHcy concentration. In multivariate models, only folate intake remained inversely associated with the plasma tHcy concentration. Mean plasma tHcy concentrations (adjusted for intakes of riboflavin, vitamin B-6, vitamin B-12, and methionine and for age, smoking, and alcohol consumption) in men with low (first quintile: 161 mug/d) and high (fifth quintile: 254 mug/d) folate intakes were 15.4 and 13.2 mu mol/L, respectively; in women, plasma tHcy concentrations were 13.7 and 12.4 mu mol/L at folate intakes of 160 and 262 mug/d, respectively. In men, the difference in the mean plasma tHcy concentration between men with low and high folate intakes was greater in smokers than in nonsmokers (2.8 compared with 1.6 mu mol/L) and greater in nondrinkers than in drinkers of >2 alcoholic drinks/d (3.5 compared with1.4 mu mol/L). In women, the association between folate intake and plasma tHcy was not modified by smoking or alcohol consumption. Conclusions: In this Dutch population, folate was the only B vitamin independently inversely associated with the plasma tHcy concentration. Changing dietary habits may substantially influence the plasma tHcy concentration inthe general population.

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Documento generato il 30/03/20 alle ore 09:55:40