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Titolo:
Vascularization of malignant and benign skin tumours measured by D-galactose-based signal-enhanced colour Doppler sonography
Autore:
Schroder, RJ; Maurer, J; Zlowodski, M; Hidajat, N; Schlums, D; Weber, S; Felix, R;
Indirizzi:
Humboldt Univ, Univ Hosp Rudolf Virchow, Charite, Dept Radiol, Berlin, Germany Humboldt Univ Berlin Germany how, Charite, Dept Radiol, Berlin, Germany Humboldt Univ, Univ Hosp Rudolf Virchow, Charite, Dept Oral & Maxillofacial Surg, Berlin, Germany Humboldt Univ Berlin Germany Oral & Maxillofacial Surg, Berlin, Germany Schering AG, D-1000 Berlin, Germany Schering AG Berlin Germany D-1000Schering AG, D-1000 Berlin, Germany
Titolo Testata:
ACTA RADIOLOGICA
fascicolo: 3, volume: 42, anno: 2001,
pagine: 294 - 301
SICI:
0284-1851(200105)42:3<294:VOMABS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRAST AGENT; DUPLEX SONOGRAPHY; BLOOD-FLOW; MELANOMA; LESIONS; ULTRASOUND; VESSELS; MODE;
Keywords:
skin tumours, colour Doppler sonography; ultrasound contrast agents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Schroder, RJ Charite, Dept Radiol, Campus Virchow Klinikum,Augustenburger Pl 1, DE-13353 Berlin, Germany Charite Campus Virchow Klinikum,Augustenburger Pl 1 Berlin Germany DE-13353
Citazione:
R.J. Schroder et al., "Vascularization of malignant and benign skin tumours measured by D-galactose-based signal-enhanced colour Doppler sonography", ACT RADIOL, 42(3), 2001, pp. 294-301

Abstract

Purpose: Evaluation of colour Doppler criteria to differentiate between malignant and benign skin tumours on the basis of the degree of vascularization. Material and Methods: The B-mode sonomorphology and the degree of vascularization in colour Doppler of 81 clinically potentially malignant tumours ofcutaneous and subcutaneous structures were analyzed and quantified by number of intratumoral vessels per sonographic slice and percentage vessel area. Results: Of all criteria employed, counting the intratumoral vessels visible on one ultrasound slice after application of a signal-enhancing agent led to highest sensitivity (94%) of all used criteria but the specificity waspoor (64%). The highest specificity (88%) and greatest diagnostic accuracy(86%) discriminating benign and malignant lesions were found using the criterion "percentage vessel area >5.0%" after all inflamed lesions had been excluded on the basis of clinical criteria. Plain colour Doppler increased the specificity up to 97%, although the sensitivity decreased simultaneouslyto max. 75%. Analysis of the B-mode morphology and spectral Doppler parameter of intratumoral vessels did not contribute to the differential diagnosis. Conclusion: Signal-enhanced colour Doppler sonography is a valuable tool in the pretherapeutic assessment of cutaneous lesions. This method may be relevant for therapy and prognosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:26:23