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Titolo:
Trigeminal neuralgia - Pathophysiology and treatment
Autore:
Joffroy, A; Levivier, M; Massager, N;
Indirizzi:
Free Univ Brussels, Hop Erasme, Serv Neurochirurg, Dept Neurosurg, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 urg, B-1070 Brussels, Belgium
Titolo Testata:
ACTA NEUROLOGICA BELGICA
fascicolo: 1, volume: 101, anno: 2001,
pagine: 20 - 25
SICI:
0300-9009(200103)101:1<20:TN-PAT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIOFREQUENCY THERMOCOAGULATION; MICROVASCULAR DECOMPRESSION; GANGLION; MICROCOMPRESSION; RADIOSURGERY; COMPRESSION; PAIN;
Keywords:
trigeminal neuralgia; pathophysiology; treatment; neurosurgery; radiosurgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Joffroy, A Free Univ Brussels, Hop Erasme, Serv Neurochirurg, Dept Neurosurg, 808 Route Lennik, B-1070 Brussels, Belgium Free Univ Brussels 808 RouteLennik Brussels Belgium B-1070 um
Citazione:
A. Joffroy et al., "Trigeminal neuralgia - Pathophysiology and treatment", ACT NEUR BE, 101(1), 2001, pp. 20-25

Abstract

Trigeminal neuralgia is a very peculiar disease. The pain, also known as "tic douloureux", is paroxystic and very severe. It can be triggered by a light cutaneous stimulus on a very localized spot on the face (thr so-called "trigger zone"). The patient can sometimes benefit from long remissions without any treatment. With the exception of multiple sclerosis and sf uncommon cases of posterior fossa tumours or other lesions impinging on the trigeminal nerve, ganglion or root, trigeminal neuralgia is considered as "idiopathic". Some benign abnormality had for long been suspected. The current opinion is now in favour of a "neurovascular conflict" : an artery, most oftena loop of the superior or antero-inferior cerebellar. artery, has an offending contact with the trigeminal nerve root, which results in localized demyelination and ectopic triggering of neuronal discharges. This hypothesis is in agreement with the relief provided by antiepileptic drugs and is supported by recent neuroimaging data. Therapeutic options are reviewed: very efficient drugs are available but fail to provide a significant relief and/or have important side effects in many cases. Surgical alternatives are available, for which guidelines are proposed

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Documento generato il 03/04/20 alle ore 03:31:59