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Titolo:
Quantitative magnetic resonance imaging in the diagnosis of Alzheimer's disease
Autore:
Schonknecht, P; Pantel, J; Schroder, J;
Indirizzi:
Univ Heidelberg, Psychiat Klin, D-69115 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69115 , D-69115 Heidelberg, Germany
Titolo Testata:
ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE
fascicolo: 2, volume: 34, anno: 2001,
pagine: 101 - 107
SICI:
0948-6704(200104)34:2<101:QMRIIT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
GER
Soggetto:
PRIMARY DEGENERATIVE DEMENTIA; VASCULAR DEMENTIA; TEMPORAL-LOBE; RATING-SCALE; ATROPHY; VOLUME; MRI; DEPRESSION; SEVERITY; PROTEIN;
Keywords:
Alzheimer's disease; magnetic resonance imaging; differential diagnosis; beta-amyloid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Schroder, J Univ Heidelberg, Psychiat Klin, Vossstr 4, D-69115 Heidelberg,Germany Univ Heidelberg Vossstr 4 Heidelberg Germany D-69115 Germany
Citazione:
P. Schonknecht et al., "Quantitative magnetic resonance imaging in the diagnosis of Alzheimer's disease", Z GERON GER, 34(2), 2001, pp. 101-107

Abstract

Alzheimer's disease (AD) is a degenerative dementing disorder which is characterised by a progressive atrophy of several brain regions. This process may be visualised in vivo by the use of magnetic resonance imaging (MRI) incombination with appropriate volumetric post-processing techniques. Recentvolumetric MRI studies in AD consistently found an extensive volume loss of the medial temporal lobe structures including amygdala and hippocampus which appeared already in the early clinical stages of the;disorder. This finding is progressive during the clinical course of AD and is associated withother biological markers of the disease such as cerebrospinal fluid betaA 4 levels and apolipoprotein E genotype. With respect to the extent and the distribution of the structural changes, AD may be differentiated from otherneuropsychiatric disorders which could facilitate the differential diagnosis in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:20:29