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Titolo:
Atypical neural messengers
Autore:
Baranano, DE; Ferris, CD; Snyder, SH;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 urosci, Baltimore, MD 21205 USA
Titolo Testata:
TRENDS IN NEUROSCIENCES
fascicolo: 2, volume: 24, anno: 2001,
pagine: 99 - 106
SICI:
0166-2236(200102)24:2<99:ANM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; METHYL-D-ASPARTATE; OLFACTORY RECEPTOR NEURONS; DEPENDENT PROTEIN-KINASE; CULTURED RAT NEURONS; MALE-MICE LACKING; D-SERINE; CARBON-MONOXIDE; NMDA RECEPTOR; HEME OXYGENASE-2;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
103
Recensione:
Indirizzi per estratti:
Indirizzo: Baranano, DE Johns Hopkins Univ, Sch Med, Dept Neurosci, 725 N Wolfe St, Baltimore, MD 21205 USA Johns Hopkins Univ 725 N Wolfe St Baltimore MD USA 21205 USA
Citazione:
D.E. Baranano et al., "Atypical neural messengers", TRENDS NEUR, 24(2), 2001, pp. 99-106

Abstract

Notions of what constitutes a neurotransmitter have changed markedly with the advent in the past decade of synaptic molecules, which satisfy key neurotransmitter criteria but differ radically from classical transmitters. Thus, NO and carbon monoxide are neither stored in synaptic vesicles nor released by exocytosis. These gases do not act via traditional receptors on postsynaptic membranes. In addition, zinc, stored together with glutamate in synaptic vesicles, appears to act as an 'antagonist' co-transmitter at the NMDA receptor, and although localized exclusively to glia, D-serine fulfills most neurotransmitter criteria as an endogenous ligand for the 'glycine' site of NMDA receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 19:58:39