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Titolo:
Developing networks play a similar melody
Autore:
Ben-Ari, Y;
Indirizzi:
INMED, INSERM U29, F-13273 Marseille 09, France INMED Marseille France 09 NMED, INSERM U29, F-13273 Marseille 09, France
Titolo Testata:
TRENDS IN NEUROSCIENCES
fascicolo: 6, volume: 24, anno: 2001,
pagine: 353 - 360
SICI:
0166-2236(200106)24:6<353:DNPASM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GIANT DEPOLARIZING POTENTIALS; NEONATAL RAT HIPPOCAMPUS; EARLY POSTNATAL LIFE; IN-VITRO; AMPA RECEPTORS; GLUTAMATE RECEPTORS; PYRAMIDAL NEURONS; RETINAL WAVES; SPINAL-CORD; CA1 REGION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Ben-Ari, Y INMED, INSERM U29, Ave Luminy,BP 13, F-13273 Marseille 09, France INMED Ave Luminy,BP 13 Marseille France 09 arseille 09, France
Citazione:
Y. Ben-Ari, "Developing networks play a similar melody", TRENDS NEUR, 24(6), 2001, pp. 353-360

Abstract

During development, when synapses start to be established, a primitive form of network-driven activity provides most of the synaptic activity. This pattern enables a high degree of synchrony in immature neurons in spite of the small number of functional synapses and could participate in activity-dependent growth and synapse formation. Relying on the giant depolarizing potentials that provide most of the synaptic activity in the developing hippocampus, this article reviews the common properties and generating mechanismsof these patterns, and particularly the role of the early depolarizing action of GABA, and glycine receptors and the sequential expression of GABA and glutamate synapses. Patterns similar to giant depolarizing potentials have been observed in a wide range of structures and species suggesting that there is a temporal template throughout evolution that constitutes an essential step in the formation of functional networks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:16:15