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Titolo:
Psychosis: pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia?
Autore:
Sharp, FR; Tomitaka, M; Bernaudin, M; Tomitaka, S;
Indirizzi:
Univ Cincinnati, Dept Neurol, Vontz Ctr, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 ntz Ctr, Cincinnati, OH 45267 USA Univ Cincinnati, Vontz Ctr, Program Neurosci, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 eurosci, Cincinnati, OH 45267 USA Tokyo Womens Med Univ, Dept Psychiat, Tokyo, Japan Tokyo Womens Med Univ Tokyo Japan Med Univ, Dept Psychiat, Tokyo, Japan
Titolo Testata:
TRENDS IN NEUROSCIENCES
fascicolo: 6, volume: 24, anno: 2001,
pagine: 330 - 334
SICI:
0166-2236(200106)24:6<330:PPAOLT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA-ANTAGONIST NEUROTOXICITY; THALAMIC RETICULAR NUCLEUS; HEAT-SHOCK GENE; RECEPTOR ANTAGONISTS; RETROSPLENIAL CORTEX; ANTIPSYCHOTIC-DRUGS; PREFRONTAL CORTEX; PHENCYCLIDINE PCP; PYRAMIDAL NEURONS; BRAIN;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Sharp, FR Univ Cincinnati, Dept Neurol, Vontz Ctr, 3125 Eden Ave Rm 2327, Cincinnati, OH 45267 USA Univ Cincinnati 3125 Eden Ave Rm 2327 Cincinnati OH USA 45267 SA
Citazione:
F.R. Sharp et al., "Psychosis: pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia?", TRENDS NEUR, 24(6), 2001, pp. 330-334

Abstract

Non-competitive NMDA receptor antagonists, such as phencyclidine. ketamineand MK801, produce psychosis in humans. These drugs also produce injury tocingulate-retrosplenial cortex in adult rodents that can be prevented by GABA-receptor agonists and antipsychotics such as haloperidol and clozapine,MK801 injections into anterior thalamus reproduce limbic cortex injury, and GABA-receptor agonist injections into anterior thalamus prevent injury produced by systemic MK801. Inhibition of NMDA receptors on GABAergic thalamic reticular nucleus neurons might activate thalamocortical 'injury' circuits in animals. Pathological activation of thalamocortical circuits might also mediate the psychosis produced by NMDA-receptor antagonists in humans, and might contribute to psychosis in schizophrenia.

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Documento generato il 22/01/20 alle ore 10:06:51