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Titolo:
Timing is everything: regulation of mitotic exit and cytokinesis by the MEN and SIN
Autore:
McCollum, D; Gould, KL;
Indirizzi:
Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, Worcester, MA 01605 USA Univ Massachusetts Worcester MA USA 01605 robiol, Worcester, MA 01605 USA Vanderbilt Univ, Howard Hughes Med Inst, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Med Inst, Nashville, TN 37232 USA Vanderbilt Univ, Dept Cell Biol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Cell Biol, Nashville, TN 37232 USA
Titolo Testata:
TRENDS IN CELL BIOLOGY
fascicolo: 2, volume: 11, anno: 2001,
pagine: 89 - 95
SICI:
0962-8924(200102)11:2<89:TIEROM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
YEAST SCHIZOSACCHAROMYCES-POMBE; SPINDLE POLE BODY; PROTEIN-TYROSINE-PHOSPHATASE; GTPASE-ACTIVATING PROTEIN; DNA-DAMAGE CHECKPOINT; CELL-DIVISION CYCLE; FISSION YEAST; SACCHAROMYCES-CEREVISIAE; BUDDING YEAST; SEPTUM FORMATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: McCollum, D Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, Worcester, MA 01605 USA Univ Massachusetts Worcester MA USA 01605 ester, MA 01605 USA
Citazione:
D. McCollum e K.L. Gould, "Timing is everything: regulation of mitotic exit and cytokinesis by the MEN and SIN", TR CELL BIO, 11(2), 2001, pp. 89-95

Abstract

Proper completion of mitosis requires careful coordination of numerous cellular events. It is crucial, for example, that cells do not initiate spindle disassembly and cytokinesis until chromosomes have been properly segregated. Cells have developed numerous safeguards or checkpoints to delay exit from mitosis and initiation of the next cell cycle in response to defects inlate mitosis. In this review, we discuss recent work on two homologous signaling pathways in budding and fission yeast, termed the mitotic exit network (MEN) and septation initiation network (SIN), respectively, that are essential for coordinating completion of mitosis and cytokinesis with other mitotic events.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:28:56