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Titolo:
Heparan sulfate: decoding a dynamic multifunctional cell regulator
Autore:
Turnbull, J; Powell, A; Guimond, S;
Indirizzi:
Univ Birmingham, Sch Biosci, Mol Cell Biol Labs, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT W Midlands, England
Titolo Testata:
TRENDS IN CELL BIOLOGY
fascicolo: 2, volume: 11, anno: 2001,
pagine: 75 - 82
SICI:
0962-8924(200102)11:2<75:HSDADM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-GLUCOSAMINYL 3-O-SULFOTRANSFERASE; MOLECULAR-CLONING; CRYSTAL-STRUCTURE; FINE-STRUCTURE; MAST-CELLS; BASIC FGF; PROTEOGLYCANS; EXPRESSION; BINDING; OLIGOSACCHARIDES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Turnbull, J Univ Birmingham, Sch Biosci, Mol Cell Biol Labs, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT England
Citazione:
J. Turnbull et al., "Heparan sulfate: decoding a dynamic multifunctional cell regulator", TR CELL BIO, 11(2), 2001, pp. 75-82

Abstract

The heparan sulfates are a family of cell-surface and matrix polysaccharides with an incredible degree of structural diversity that are distributed widely in virtually all metazoan organisms. Recent genetic, biochemical and cell-biological studies have led to increased understanding of the biosynthetic mechanisms that produce these complex molecules, as well as their functional versatility in regulating protein activities. The dynamic expressionof heparan sulfates with differing sugar sequences suggests a new concept in which the repertoire of sequences produced by a particular cell or tissue is designated its 'heparanome'. This review discusses recent developmentsand surveys emerging experimental strategies that hold promise for revealing the functional specificity and mechanisms of action of heparan sulfates as multifunctional cell regulators.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:56:08