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Titolo:
Nitric oxide and the regulation of gene expression
Autore:
Bogdan, C;
Indirizzi:
Univ Erlangen Nurnberg, Inst Clin Microbiol Immunol & Hyg, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany
Titolo Testata:
TRENDS IN CELL BIOLOGY
fascicolo: 2, volume: 11, anno: 2001,
pagine: 66 - 75
SICI:
0962-8924(200102)11:2<66:NOATRO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FINGER TRANSCRIPTION FACTORS; HYPOXIA-INDUCIBLE FACTOR-1; MACROPHAGE IRON-METABOLISM; SOLUBLE GUANYLATE-CYCLASE; KAPPA-B ACTIVITY; DNA-BINDING; SIGNAL-TRANSDUCTION; TYROSINE NITRATION; INTERFERON-GAMMA; RESPONSE ELEMENT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Bogdan, C Univ Erlangen Nurnberg, Inst Clin Microbiol Immunol & Hyg, Wasserturmstr 3, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Wasserturmstr 3 Erlangen Germany D-91054
Citazione:
C. Bogdan, "Nitric oxide and the regulation of gene expression", TR CELL BIO, 11(2), 2001, pp. 66-75

Abstract

During the past 15 years, nitric oxide (NO) and NO synthases have become an important research topic in cellular and molecular biology. NO is produced by many ii not all mammalian cells and fulfils a broad spectrum of signaling functions in physiological and pathophysiological processes. In this review, recent advances in our understanding of the mechanisms by which NO regulates the expression of eukaryotic genes will be summarized. The currently available data illustrate that NO has multiple molecular targets: it can not only directly influence the activity of transcription factors but also modulates upstream signaling cascades, mRNA stability and translation, as well as the processing of the primary gene products.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:18:22