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Titolo:
Effect of exposure to nitrogen dioxide on alveolar macrophage-mediated immunosuppressive activity in rats
Autore:
Koike, E; Kobayashi, T; Utsunomiya, R;
Indirizzi:
Natl Inst Environm Studies, Environm Hlth Sci Div, Tsukuba, Ibaraki 3050053, Japan Natl Inst Environm Studies Tsukuba Ibaraki Japan 3050053 i 3050053, Japan Univ Tsukuba, Dept Med, Tsukuba, Ibaraki 305, Japan Univ Tsukuba Tsukuba Ibaraki Japan 305 t Med, Tsukuba, Ibaraki 305, Japan Univ Tsukuba, Inst Biol Sci, Tsukuba, Ibaraki 3058575, Japan Univ TsukubaTsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 2, volume: 121, anno: 2001,
pagine: 135 - 143
SICI:
0378-4274(20010430)121:2<135:EOETND>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; T-CELL ACTIVATION; AIRWAY HYPERRESPONSIVENESS; GUINEA-PIGS; SHORT-TERM; RESPONSES; PROLIFERATION; INDUCTION; PROSTAGLANDINS; SUPPRESSION;
Keywords:
nitrogen dioxide; alveolar macrophages; immunosuppressive activity; nitric oxide; bronchoalveolar lavage fluid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Kobayashi, T Natl Inst Environm Studies, Environm Hlth Sci Div, Tsukuba, Ibaraki 3050053, Japan Natl Inst Environm Studies Tsukuba Ibaraki Japan 3050053 pan
Citazione:
E. Koike et al., "Effect of exposure to nitrogen dioxide on alveolar macrophage-mediated immunosuppressive activity in rats", TOX LETT, 121(2), 2001, pp. 135-143

Abstract

Nitrogen dioxide (NO2), a major component of air pollutants, induces inflammatory responses in the lungs. Resident alveolar macrophages (AM) play an immunosuppressive role in the lungs via suppression of lymphocyte proliferation, and nitric oxide (NO) plays a crucial role in this immunosuppressive activity. Microenvironmental changes within the alveoli during inflammatoryresponses, however, can inhibit this immunosuppressive activity of AM. Thepresent study was designed to clarify the effect of NO2 exposure on the immunosuppressive activity of and NO production by AM in rats, Wistar rats were exposed to 10 ppm NO2 for 3, 14 or 28 days, after which bronchoalveolar lavage fluid (BALF) was taken as a sample of the alveolar microenvironment. Suppression of concanavalin A-induced lymphocyte proliferation and NO production by AM were markedly inhibited by BALF from NO2-exposed rats (NO2-BALF), The inhibitory effect of NO2-BALF at 28-days exposure was stronger thanthat of NO2-BALF at 3 or 14 days exposure. In conclusion, AM-mediated immunosuppressive activity was inhibited by the NO2-induced changes of the alveolar microenvironment through the inhibition of NO production. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:36:02