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Titolo:
Opiate modulation of hemodynamic, hormonal, and cytokine responses to hemorrhage
Autore:
Molina, PE;
Indirizzi:
Louisiana State Univ, Hlth Sci Ctr, Dept Physiol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA
Titolo Testata:
SHOCK
fascicolo: 6, volume: 15, anno: 2001,
pagine: 471 - 478
SICI:
1073-2322(200106)15:6<471:OMOHHA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC NERVOUS-SYSTEM; MESSENGER-RNA EXPRESSION; RECEPTOR BLOCKADE; HYPOVOLEMIC SHOCK; ALPHA PRODUCTION; BETA-ENDORPHIN; CELL-ACTIVITY; MORPHINE; RAT; MICE;
Keywords:
naltrexone; beta-endorphin; hemorrhagic shock; TNF-alpha; IL-1; IL-6; corticosterone; catecholamines; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Molina, PE Louisiana State Univ, Hlth Sci Ctr, Dept Physiol, 1901 Perdido St, New Orleans, LA 70112 USA Louisiana State Univ 1901 Perdido St New Orleans LA USA 70112 A
Citazione:
P.E. Molina, "Opiate modulation of hemodynamic, hormonal, and cytokine responses to hemorrhage", SHOCK, 15(6), 2001, pp. 471-478

Abstract

The aim of the present study was to examine the role of opiate receptor activation in modulating the hemodynamic, neuroendocrine, and tissue (lung and spleen) cytokine responses to fixed pressure (40 mm Hg) hemorrhage. Chronically catheterized, conscious unrestrained non-heparinized male Sprague-Dawley rats were pretreated with either naltrexone (15 mg/kg intraperitoneally in 0.5 mL of saline) or saline (0.5 mL) 15 min prior to hemorrhage followed by fluid resuscitation with Ringer's lactate. Animals were sacrificed atcompletion of the 60-min resuscitation period. Blood loss required to achieve mean arterial blood pressure (MABP) of 40 mm Hg was higher in naltrexone-treated animals than in time-matched saline controls (4.4 +/- 0.2 versus 3.7 +/- 0.2 mL/100 g BW, P < 0.05). Hemorrhage increased plasma levels of corticosterone (30%) and ACTH (3-fold) within 15 min. Naltrexone prevented the hemorrhage-induced rise in corticosterone without affecting the rise in ACTH. Hemorrhage increased <beta>-endorphin levels (4-fold) and produced animmediate (5 min) and progressive increase in circulating epinephrine and norepinephrine levels reaching values that were 50- and 20-fold, respectively, higher than basal. Pre-treatment with naltrexone did not alter the timecourse or magnitude of the hemorrhage-induced increases in plasma beta -endorphin or catecholamines. Hemorrhage increased lung and spleen content of TNF (60%), IL-1 alpha (300%), IL-6 (40%-60%), and IL-10 (80%) above values of time-matched sham control animals. Pre-treatment with naltrexone bluntedthe magnitude of the increases in tissue cytokine content in response to agiven blood loss. These results indicate that endogenous opiates modulate the hemodynamic instability, neuroendocrine, and cytokine responses to hemorrhagic shock.

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Documento generato il 31/03/20 alle ore 22:36:17